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Splenic and lung response to nonlethal systemic Aspergillus fumigatus infection in C57BL/6 mice
dc.creator | Mirkov, Ivana | |
dc.creator | Stojanović, Ivana D. | |
dc.creator | Stošić-Grujičić, Stanislava | |
dc.creator | Glamočlija, Jasmina | |
dc.creator | Zolotarevski, Lidija D | |
dc.creator | Kataranovski, Dragan S. | |
dc.creator | Kataranovski, Milena | |
dc.date.accessioned | 2017-11-23T11:11:00Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2010 | sr |
dc.identifier.issn | 1369-3786 | sr |
dc.identifier.other | Rad_konverzija_3354 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1359 | |
dc.description.abstract | In this study, we investigated splenic and lung cell responses to nonlethal systemic Aspergillus fumigatus infection in mice. Apart from basic indices of spleen and lung cell activity, IL-17 expression by cells from both tissues was determined and compared to the expression of IFN-gamma and IL-4. Progressive decrease in tissue fungal burden correlated with increased spleen and lung cell activity. Increased IL-17 message was noted in spleen cells at all time points (3, 7 and 15 days post-infection; p.i.), while a modest increase in IFN-gamma mRNA expression was noted at day 3 p.i. Increased cytokine production at days 3 and 7 (IL-17) and throughout the experimental period (IFN-gamma) was found. In contrast, spleen cell IL-4 expression was considerably lower during infection, resulting in high IFN-gamma/IL-4 and IL-17/IL-4 ratios in the spleen. Pro-inflammatory cytokine response was observed in the lungs as well, but primarily as the result of increased production of IFN-gamma by lung cells in response to challenge with conidia and the absence of change in IL-4 response. Increased activity of cells from both tissues, as well as the pattern of cytokine production, created an optimal pro-inflammatory milieu for fungal eradication. | en |
dc.description.sponsorship | Ministry of Science and Technological Development of the Republic of Serbia [143038, 143029] | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Medical Mycology | sr |
dc.title | Splenic and lung response to nonlethal systemic Aspergillus fumigatus infection in C57BL/6 mice | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Золотаревски, Лидија Д; Катарановски, Драган С.; Стошић-Грујичић, Станислава Д.; Катарановски, Милена В.; Стојановић, Ивана; Мирков, Ивана; Гламочлија, Јасмина; | |
dc.citation.issue | 5 | sr |
dc.citation.volume | 48 | sr |
dc.citation.epage | 743 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1359 |
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