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Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: Protective role of coenzyme Q(10) and Vitamin E
dc.creator | Ognjanović, Branka I | |
dc.creator | Marković, Snezana D | |
dc.creator | Đorđević, Natasa Z | |
dc.creator | Trbojević, Ivana S | |
dc.creator | Stajn, Andras S | |
dc.creator | Saičić, Zorica | |
dc.date.accessioned | 2017-11-23T11:10:54Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2010 | sr |
dc.identifier.issn | 0890-6238 | sr |
dc.identifier.other | Rad_konverzija_3388 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1393 | |
dc.description.abstract | The aim of this study was to investigate the protective role of coenzyme Q(10) (CoQ(10), 20 mg/kg) and Vitamin E (Vit E, 20IU/kg) alone or in combination against cadmium (Cd, 0.4 mg/kg) induced lipid peroxidation and changes in antioxidant defense system in the rat testes. The obtained results showed that Cd increased lipid peroxidation in the testes, suggesting that Cd-induced oxidative stress, while CoQ(10) and Vit E treatment reversed this change to control values. Acute intoxication with Cd was followed by significantly decreased activity of antioxidant enzymes (SOD, CAT, GSH-Px, GR and GST). Vitamins C and E concentrations also significantly declined in Cd-exposed rat testes. Treatment with CoQ(10), and Vit E reversed Cd-induced alterations of antioxidant defense system and significantly prevented Cd-induced testes damage. These results suggest that both CoQic, and Vit E function as a potent antioxidant in protection of rats testes against the oxidative stress induced by Cd. (C) 2009 Elsevier Inc. All rights reserved. | en |
dc.description.sponsorship | Ministry of Science and Technological Development of Republic of Serbia [143035B] | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Reproductive Toxicology | sr |
dc.title | Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: Protective role of coenzyme Q(10) and Vitamin E | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Стајн, Aндрас С; Огњановић, Бранка И; Трбојевић, Ивана С; Ђорђевић, Натаса З; Марковић, Снезана Д; Саичић, Зорица; | |
dc.citation.issue | 2 | sr |
dc.citation.volume | 29 | sr |
dc.citation.epage | 197 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1393 |
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