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Lipid status, anti-oxidant enzyme defence and haemoglobin content in the blood of long-term clozapine-treated schizophrenic patients
dc.creator | Miljević, Cedo D | |
dc.creator | Nikolić, Milan R | |
dc.creator | Nikolić-Kokić, Aleksandra | |
dc.creator | Jones, David R | |
dc.creator | Niketić, Vesna P | |
dc.creator | Lecić-Tosevski, Dusica M | |
dc.creator | Spasić, Mihajlo | |
dc.date.accessioned | 2017-11-23T11:11:00Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2010 | sr |
dc.identifier.issn | 0278-5846 | sr |
dc.identifier.other | Rad_konverzija_3390 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1395 | |
dc.description.abstract | Objective: Despite clozapine's unique effectiveness in patients with schizophrenia, a number of adverse effects have been recognised including abnormalities in lipid and glucose metabolisms. A high clozapine level in red blood cells (RBCs) and disturbed anti-oxidant enzyme activities in blood from schizophrenic patients prompted us to investigate lipid status and anti-oxidant enzyme defence in the blood of chronic schizophrenic patients on long-term clozapine therapy. Methods: Plasma lipids, RBC anti-oxidant enzyme activities and haemoglobin (Hb) content were measured using established procedures in a group of eighteen chronically-medicated (average 630 days of therapy) schizophrenic patients receiving clozapine (average dose of 295 mg/day) and data were compared with those from a group of eighteen well-matched normal controls. Results: Significantly higher levels of plasma triglycerides (by 47%, p<0.01) and total cholesterol and phospholipids (by 8% and 11%, respectively p<0.05) in patients were found. CuZn-superoxide dismutase (SOD1) activity was markedly higher (by 35%, p<0.001) while selenium-dependent glutathione peroxidase (GSH-Px1) activity was markedly lower (by 41%, p<0.001) in patients. In addition, metHb and HbA1c levels in patients were significantly higher (by 58% and 25%. respectively p<0.001). SOD1 activity was negatively correlated (p<0.001) to GSH-Px1 activity in patients. Conclusions:The findings support the view that ongoing oxidative stress may be a mechanism by which clozapine induces some adverse effects that increase the risk of diabetes and metabolic syndrome. If valid, this would indicate that in parallel with long-term clozapine treatment, schizophrenic patients could be encouraged to make some lifestyle changes to limit the detrimental effects of the medication. (C) 2009 Elsevier Inc. All rights reserved. | en |
dc.description.sponsorship | Ministry of Science and Technological Development of the Republic of Serbia [142017, 143034] | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Progress in Neuro-Psychopharmacology & Biological Psychiatry | sr |
dc.title | Lipid status, anti-oxidant enzyme defence and haemoglobin content in the blood of long-term clozapine-treated schizophrenic patients | en |
dc.type | review | |
dc.rights.license | ARR | |
dcterms.abstract | Јонес, Давид Р; Никетић, Весна П; Спасић, Михајло Б.; Николић-Кокић, Aлександра; Миљевић, Цедо Д; Николић, Милан Р; Лецић-Тосевски, Дусица М; | |
dc.citation.issue | 2 | sr |
dc.citation.volume | 34 | sr |
dc.citation.epage | 307 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1395 |
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