Morphofunctional characteristics of ACTH cells in middle-aged male rats after treatment with genistein
2009
Autori:
Milošević, VericaAjdžanović, Vladimir
Šošić-Jurjević, Branka
Filipović, Branko
Brkić, Marjana P.
Nestorović, Nataša
Sekulić, Milka I.
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
The soybean phytoestrogen, genistein, is increasingly consumed as an alternative therapeutic for age-related diseases. The aim of this study was to examine the morphofunctional characteristics of adrenocorticotrophic (ACTH) cells and blood concentrations of ACTH in sham-operated, orchidectomized and genistein-treated orchidectomized, 16-month-old Wistar male rats. Genistein (10 mg/kg/day) was administered subcutaneously for three weeks, while the control groups received the vehicle alone. Orchidectomy and genistein treatment decreased the volume density of ACTH cells and reduced (p < 0.05) circulating ACTH concentrations in comparison with control groups. In conclusion, genistein modulated the morphofunctional features of ACTH cells and decreased blood ACTH levels.
Izvor:
General Physiology and Biophysics, 2009, 28, 1, 94-97
DOI: 10.4149/gpb_2009_01_94
ISSN: 0231-5882
PubMed: 19390142