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Morphofunctional characteristics of ACTH cells in middle-aged male rats after treatment with genistein
| dc.creator | Milošević, Verica | |
| dc.creator | Ajdžanović, Vladimir | |
| dc.creator | Šošić-Jurjević, Branka | |
| dc.creator | Filipović, Branko | |
| dc.creator | Brkić, Marjana P. | |
| dc.creator | Nestorović, Nataša | |
| dc.creator | Sekulić, Milka I. | |
| dc.date.accessioned | 2017-11-23T11:12:52Z | |
| dc.date.available | 2900-01-01 | |
| dc.date.issued | 2009 | sr |
| dc.identifier.issn | 0231-5882 | sr |
| dc.identifier.other | Rad_konverzija_3457 | sr |
| dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1462 | |
| dc.description.abstract | The soybean phytoestrogen, genistein, is increasingly consumed as an alternative therapeutic for age-related diseases. The aim of this study was to examine the morphofunctional characteristics of adrenocorticotrophic (ACTH) cells and blood concentrations of ACTH in sham-operated, orchidectomized and genistein-treated orchidectomized, 16-month-old Wistar male rats. Genistein (10 mg/kg/day) was administered subcutaneously for three weeks, while the control groups received the vehicle alone. Orchidectomy and genistein treatment decreased the volume density of ACTH cells and reduced (p < 0.05) circulating ACTH concentrations in comparison with control groups. In conclusion, genistein modulated the morphofunctional features of ACTH cells and decreased blood ACTH levels. | en |
| dc.description.sponsorship | Ministry for Science of Serbia [143007B] | sr |
| dc.language.iso | English | sr |
| dc.publisher | Bratislava: Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences | |
| dc.rights | restrictedAccess | |
| dc.source | General Physiology and Biophysics | sr |
| dc.title | Morphofunctional characteristics of ACTH cells in middle-aged male rats after treatment with genistein | en |
| dc.type | article | |
| dc.rights.license | ARR | |
| dcterms.abstract | Aјджановић, Владимир; Филиповић, Бранко; Шошић-Јурјевић, Бранка Т.; Несторовић, Наташа М.; Секулић, Милка И.; Бркић, Марјана П.; Милошевић, Верица Љ.; | |
| dc.rights.holder | © Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences | |
| dc.citation.issue | 1 | sr |
| dc.citation.volume | 28 | sr |
| dc.identifier.doi | 10.4149/gpb_2009_01_94 | |
| dc.identifier.pmid | 19390142 | |
| dc.identifier.scopus | 2-s2.0-65349120032 | |
| dc.identifier.wos | 000265285000012 | |
| dc.citation.spage | 94 | |
| dc.citation.epage | 97 | sr |
| dc.type.version | publishedVersion | en |
| dc.citation.rank | M23 | |
| dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1462 |
