Effect of continuous exposure to alternating magnetic field (50 Hz, 0.5 mT) on serotonin and dopamine receptors activity in rat brain
2009
Аутори:
Petković, BrankaTovilović-Kovačević, Gordana
Tomić, Mirko
Prolić, Zlatko M.
Radenović, Lidija Lj
Тип документа:
Чланак у часопису (Објављена верзија)
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© Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences
Метаподаци
Приказ свих података о документуАпстракт:
External magnetic fields (MFs) have the ability to modify motor activity of animals, complex type of behaviour connected with dopaminergic and serotonergic neurotransmissions in the brain. Thus, the purpose of this study was to examine MF-induced changes in the activity of serotonin 5-HT(2A) receptors in the prefrontal cortex, as well as dopamine D(1) and D(2) receptors in the striatum of adult Wistar rats, considering their involvement in motor behavior regulation. Experimental animals were continuously exposed to extremely low frequency MF (ELF-MF, 50 Hz, 0.5 mT) for 1, 3, and 7 days. Subsequently, binding properties (K(d) and B(max)) of receptors were determined by in vitro radioligand receptor binding assays. It was shown that the affinity of serotonin 5-HT(2A) receptors decreased and their density increased in the prefrontal cortex of rats after ELF-MF exposure. Regarding affinity, this effect was duration-dependent and most prominent after 7-day of ELF-MF exposure. In contrast to serotonin 5-HT(2A) receptors in the prefrontal cortex, ELF-MF had no significant effect on the affinity and density of dopamine D(1) and D(2) receptors in the striatum. We can conclude that continuous exposure to ELF-MF up to 7 days affects cortical serotonergic neurotransmission, whereby intensity of these changes depends on ELF-MF exposure duration.
Кључне речи:
50 Hz magnetic field; Serotonin 5-HT2A receptors; Dopamine D-1 and D-2 receptors; Brain; RatsИзвор:
General Physiology and Biophysics, 2009, 28, Special Issue, 41-46Финансирање / пројекти:
- Утицај магнетних поља као екофизиолошког фактора на различите биолошке системе и могућа примена у биомедицини (RS-MESTD-MPN2006-2010-143027)
- Биомедицинска испитивања и развој неких нових психотропних супстанци (RS-MESTD-MPN2006-2010-143032)