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Effects of protamine sulphate on spontaneous and calcium-induced contractile activity in the rat uterus are potassium channels-mediated
dc.creator | Blagojević, Duško | |
dc.creator | Oreščanin Dušić, Zorana | |
dc.creator | Milovanović, Slobodan R | |
dc.creator | Radojičić, Ratko M. | |
dc.creator | Nikolić-Kokić, Aleksandra | |
dc.creator | Appiah, Isabella | |
dc.creator | Slavić, Marija | |
dc.creator | Cutura, Neđo D | |
dc.creator | Trbojević, Stevan | |
dc.creator | Spasić, Mihajlo | |
dc.date.accessioned | 2017-11-23T11:27:36Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2009 | sr |
dc.identifier.issn | 0231-5882 | sr |
dc.identifier.other | Rad_konverzija_3470 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1475 | |
dc.description.abstract | Protamine sulphate (PS) effect on spontaneous and calcium-induced rhythmic contractions of isolated virgin rat uteri was studied. PS caused dose-dependent relaxation of both types of contractions (two-way ANOVA, significant dose effects). Pretreatment with NG-nitro-L-arginine methyl ester (L-NAME; 10(-5) mol/l), methylene blue (MB; 0.9 x 10(-6) mol/l) or propranolol (1.7 x 10(-5) mol/l) enhanced PS-mediated uterine muscle relaxation of spontaneous contractions. Dose-dependent relaxation of spontaneous active isolated rat uterus with PS was lower in uteri pretreated with single dose of tetraethylammonium (TEA; 6 x 10(-3) mol/l), glibenclamide (2 x 10(-6) mol/l) and 4-aminopyridine (4-AP; 10(-3) mol/l). Calcium-induced activity of the isolated rat uterus pretreated with the same concentration of L-NAME, MB, or propranolol modified the kinetic of PS-induced relaxation without changes in EC(50) values. Pre-treatment with glibenclamide, TEA and 4-AP significantly reduce PS relaxing effect of calcium-induced activity and according to EC(50) values the order of magnitude was glibenclamide > TEA > 4-AP. PS is mixture of polyamines and may activate different signal-transduction pathways. Our results cleary demonstrate that in uterine smooth muscle PS act dominantly through potassium chanels and marginaly through beta-adrenergic receptos or nitric oxide-dependent pathways. | en |
dc.description.sponsorship | Ministry of Science of the Republic of Serbia [143034B] | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | General Physiology and Biophysics | sr |
dc.title | Effects of protamine sulphate on spontaneous and calcium-induced contractile activity in the rat uterus are potassium channels-mediated | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Благојевић, Душко П.; Миловановић, Слободан Р; Орешчанин Душић, Зорана; Николић-Кокић, Aлександра; Спасић, Михајло Б.; Трбојевић, Стеван; Цутура, Неђо Д; Славић, Марија; Aппиах, Исабелла; Радојичић, Ратко М.; | |
dc.citation.issue | null | sr |
dc.citation.volume | 28 | sr |
dc.citation.epage | 148 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M23 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1475 |
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