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Methylprednisolone inhibits interleukin-17 and interferon-gamma expression by both naive and primed T cells
dc.creator | Momčilović, Miljana | |
dc.creator | Miljković, Zeljka | |
dc.creator | Popadić, Dusan M | |
dc.creator | Marković, Milos | |
dc.creator | Savić, Emina | |
dc.creator | Ramić, Zorica D. | |
dc.creator | Miljković, Đorđe | |
dc.creator | Mostarica-Stojković, Marija B | |
dc.date.accessioned | 2017-11-23T11:12:45Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2008 | sr |
dc.identifier.issn | 1471-2172 | sr |
dc.identifier.other | Rad_konverzija_3514 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1519 | |
dc.description.abstract | Background: Interleukin-17 (IL-17)-producing cells are increasingly considered to be the major pathogenic population in various autoimmune disorders. The effects of glucocorticoids, widely used as therapeutics for inflammatory and autoimmune disorders, on IL-17 generation have not been thoroughly investigated so far. Therefore, we have explored the influence of methylprednisolone (MP) on IL-17 expression in rat lymphocytes, and compared it to the effect of the drug on interferon (IFN)-gamma. Results: Production of IL-17 in mitogen-stimulated lymph node cells (LNC) from non-treated rats, as well as in myelin basic protein (MBP)-stimulated draining LNC from rats immunized with spinal cord homogenate and complete Freund's adjuvant was significantly reduced by MP. The reduction was dose-dependent, sustained through the follow-up period of 48 hours, and was not achieved through anti-proliferative effect. Additionally, MP inhibited IL-17 production in purified T cells as well, but to less extent than in LNC. In its influence on IL-17 production MP inhibited Ror-gamma T transcription factor expression, as well as Jun phosphorylation, but not ERK or p38 activation in mitogen-stimulated LNC. Importantly, MP collaborated with IFN-gamma in inhibiting IL-17 generation in LNC. Conclusion: The observed difference in the effect of MP on IL-17 and IFN-gamma could be important for the understanding of the variability in the efficiency of glucocorticoids in the treatment of autoimmune diseases. | en |
dc.description.sponsorship | Serbian Ministry of Science [143029A, 145066A]; Alexander von Humboldt Foundation (Bonn, Germany) | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Bmc Immunology | sr |
dc.title | Methylprednisolone inhibits interleukin-17 and interferon-gamma expression by both naive and primed T cells | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Попадић, Дусан М; Миљковић, Ђорђе М.; Момчиловић, Миљана Б.; Мостарица-Стојковић, Марија Б; Рамић, Зорица Д.; Савић, Емина; Марковић, Милос; Миљковић, Зељка; | |
dc.citation.issue | null | sr |
dc.citation.volume | 9 | sr |
dc.citation.epage | na | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M22 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1519 |
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