Therapeutic effects of combined treatment with ribavirin and tiazofurin on experimental autoimmune encephalomyelitis development: Clinical and histopathological evaluation
2008
Аутори:
Savić, DanijelaLavrnja, Irena
Peković, Sanja
Dacić, Sanja
Bjelobaba, Ivana
Mostarica-Stojković, Marija B
Stošić-Grujičić, Stanislava
Jovanović, Saša
Nedeljković, Nadežda N.
Rakić, Ljubisav
Stojiljković, Mirjana B.
Тип документа:
Чланак у часопису (Објављена верзија)
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© Springer Science+Business Media, LLC 2007
Метаподаци
Приказ свих података о документуАпстракт:
Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS) and the helpful tool in preclinical testing of various substances considered for treatment of this human CNS disease. Ribavirin (R) and tiazofurin (T) are purine nucleoside analogues, with the broad spectrum of anti-viral, anti-tumoral and anti-inflammatory properties. We proposed that combined treatment with RT, administrated during the effector phase of EAE, would attenuate disease severity, both clinically and pathologically. Ribavirin was given daily at a dosage of 30 mg/kg and tiazofurin was given at a dosage of 10 mg/kg every other day for 15 days. We detected amelioration of clinical signs and faster recovery in the RT group compared to the control group. Immunohistochemical analyses revealed that RT treatment decrease the number of T cells, macrophages and microglia. In the controls, we detected reactive type of microglia, while in the RT group we noticed ramified/resting form. Demyelination areas and axonal damage were not recorded in the RT group, in contrast to the control group where multiple areas of demyelination zones and axonal loss were found. RT combination treatment suppresses ongoing EAE, prevents demyelination and axonal loss, and therefore may well be the potential therapy for the treatment of MS. (C) 2007 Elsevier B.V. All rights reserved.
Кључне речи:
experimental autoimmune encephalomyelitis; multiple sclerosis; immunosupression; ribavirin; tiazofurin; combination therapyИзвор:
Journal of the Neurological Sciences, 2008, 267, 1-2, 76-85Финансирање / пројекти:
- Интеракција глије и неурона у процесу опоравка након оштећења централног нервног система (RS-MESTD-MPN2006-2010-143005)
DOI: 10.1016/j.jns.2007.10.010
ISSN: 0022-510X
PubMed: 17996253