Dietary restriction modulates alpha-synuclein expression in the aging rat cortex and hippocampus
2007
Autori:
Mladenović, AleksandraPerović, Milka
Tanić, Nikola T
Petanceska, Suzana
Ruždijić, Sabera
Kanazir, Selma
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Dietary restriction (DR) is one of the promising environmental interventions known to attenuate aging and decrease risk of age-related neurodegenerative disorders. The aim of this study was to assess the effects of DR on expression of a-synuclein, a presynaptic protein involved in pathogenesis of Parkinson's and some other neurodegenerative diseases, in the cortex and hippocampus of adult, middle-aged, late middle-aged, and aged rats. Using Real Time RT-PCR, the authors report that aging regulates the expression of alpha-synuclein in a tissue-specific manner and that long-term DR reverts the late age-related changes of alpha-synuclein expression. (c) 2007 Wiley-Liss, Inc.