Immunolocalization of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) in the rat forebrain
2006
Authors:
Bjelobaba, IvanaNedeljković, Nadežda N.
Šubašić, Sanja A
Lavrnja, Irena
Peković, Sanja
Savić, Danijela
Rakić, Ljubisav
Stojiljković, Mirjana B
Document Type:
Article (Published version)
,
© 2006 Elsevier B.V.
Metadata
Show full item recordAbstract:
Immunohistochemical study was performed to determine distribution of ecto-nucleotide pyrophosphatase/phosphodiesterase1 (NPP1) in adult rat forebrain. The study revealed widespread distribution of NPP1 in rat forebrain, yet with regional differences in the expression pattern and abundance. Strong NPP1 immunoreaction was detected in pyramidal cell layer of cerebral cortex and hippocampus, and in the midline regions of hypothalamus and thalamus. In many immunopositive forebrain areas, NPP1 was mainly localized at neuronal cell bodies. However, prominent immunoreaction was also detected at ependymal cells, tanycytes, endothelial cells of the capillaries and cells of the choroid plexus, suggesting that NPP1 could be involved in some highly specialized transport process.
Keywords:
Ecto-nucleotide pyrophosphatase/phosphodiesterase; NPP1; ATP-dependent processes; Brain; ImmunohistochemistrySource:
Brain Research, 2006, 1120, 1, 54-63Funding / projects:
- Interakcija glije i neurona u procesu oporavka nakon oštećenja centralnog nervnog sistema (RS-MESTD-MPN2006-2010-143005)
DOI: 10.1016/j.brainres.2006.08.114
ISSN: 0006-8993
PubMed: 17046728