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Combined effects of coenzyme Q(10) and Vitamin E in cadmium induced alterations of antioxidant defense system in the rat heart
dc.creator | Ognjanović, Branka I | |
dc.creator | Marković, Snezana D | |
dc.creator | Pavlović, Slađan | |
dc.creator | Žikić, Radoslav V. | |
dc.creator | Stajn, Andras S | |
dc.creator | Saičić, Zorica | |
dc.date.accessioned | 2017-11-23T11:15:14Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2006 | sr |
dc.identifier.issn | 1382-6689 | sr |
dc.identifier.other | Rad_konverzija_3629 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1634 | |
dc.description.abstract | Our study investigated the possible protective effects of coenzyme Q(10) (CoQ(10)) and Vitamin E (Vit E) alone or in combination against cadmium (Cd) induced alterations of antioxidant defense system in the rat heart. Male Wistar rats were injected with a single dose of CdCl(2) (0.4 mg Cd/kg BW i.p.), CoQ(10) (20 mg CoQ(10)/kg BW i.m.) and Vit E (20 IU Vit E/kg BW i.m.), alone or in combination. Acute intoxication of rats with Cd were followed by significantly increased activity of antioxidant defense enzymes (CuZn SOD, GSH-Px, GST and GR), while the activity of Mn SOD was decreased in the heart. The treatment with Cd significantly decreased Vit C and Vit E concentrations. Treatment with CoQ10 and Vit E reversed Cd-induced alterations of antioxidant defense system. The obtained results support the assumption that CoQ10 and Vit E functions cooperatively with endogenous antioxidants and diminished toxic effects of Cd in rat heart. (c) 2006 Elsevier B.V. All rights reserved. | en |
dc.description.sponsorship | null | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Environmental Toxicology and Pharmacology | sr |
dc.title | Combined effects of coenzyme Q(10) and Vitamin E in cadmium induced alterations of antioxidant defense system in the rat heart | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Саичић, Зорица; Павловић, Слађан З.; Стајн, Aндрас С; Жикић, Радослав В.; Огњановић, Бранка И; Марковић, Снезана Д; | |
dc.citation.issue | 2 | sr |
dc.citation.volume | 22 | sr |
dc.citation.epage | 224 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M22 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1634 |
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