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The mechanisms of 6-hydroxydopamineInduced astrocyte death
dc.creator | Zogović, Nevena | |
dc.creator | Mladenović, Aleksandra | |
dc.creator | Perović, Milka | |
dc.creator | Miljković, Đorđe | |
dc.creator | Trajković, Vladimir S | |
dc.date.accessioned | 2017-11-23T11:15:09Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2005 | sr |
dc.identifier.issn | 0077-8923 | sr |
dc.identifier.other | Rad_konverzija_3635 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1640 | |
dc.description.abstract | Treatment with 6-hydroxydopamine significantly reduced the viability of cultured rat primary astrocytes, rat astrocytoma cell line C6, and human astrocytoma cell line U251. 6-Hydroxydopamine-treated astrocytes exhibited altered nuclear morphology, DNA fragmentation, and reduced intracellular esterase activity, which indicated apoptotic cell death. Astrocytes were protected by neutralization of 6-hydroxydopamine autooxidation products H2O2, O-2, and -OH, but not by cell-derived or chemically generated anti-apoptotic free radical nitric oxide. Finally, 6-hydroxydopamine activated extracellular signal-regulated kinase in astrocytes and selective inhibitor of extracellular signal-regulated kinase activation partially prevented astrocyte death. Taken together, these data indicate that 6-hydroxydopamine-triggered oxidative stress induces extracellular signal-regulated kinase-dependent apoptotic death of astrocytes. | en |
dc.description.sponsorship | null | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Biophysics from Molecules to Brain: in Memory of Radoslav K. Andjus | sr |
dc.title | The mechanisms of 6-hydroxydopamineInduced astrocyte death | en |
dc.type | conferenceObject | |
dc.rights.license | ARR | |
dcterms.abstract | Трајковић, Владимир С; Миљковић, Ђорђе М.; Раицевић, Невена; Младеновић Ђорђевић, Aлександра; Перовић, Милка; | |
dc.citation.issue | null | sr |
dc.citation.volume | 1048 | sr |
dc.citation.epage | 405 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1640 |
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