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Interleukin-17 stimulates inducible nitric oxide synthase-dependent toxicity in mouse beta cells
dc.creator | Miljković, Đorđe | |
dc.creator | Stojanović, Ivana D. | |
dc.creator | Momčilović, Miljana | |
dc.creator | Maksimović-Ivanić, Danijela | |
dc.creator | Stošić-Grujičić, Stanislava | |
dc.creator | Trajković, Vladimir S | |
dc.date.accessioned | 2017-11-23T11:15:17Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2005 | sr |
dc.identifier.issn | 1420-682X | sr |
dc.identifier.other | Rad_konverzija_3681 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1686 | |
dc.description.abstract | The influence of the proinflammatory cytokine interleukin (IL)-17 on inducible nitric oxide (NO) synthase (iNOS)-mediated NO release was investigated in the mouse insulinoma cell line MIN6 and mouse pancreatic islets. IL-17 markedly augmented iNOS mRNA/protein expression and subsequent NO production induced in MIN6 cells or pancreatic islets by different combinations of interferon-gamma, tumor necrosis factor-alpha, and IL-1 beta. The induction of iNOS by IL-17 was preceded by phosphorylation of p38 mitogen-activated protein kinase (MAPK), and inhibition of p38 MAPK activation completely abolished IL-17-stimulated NO release. IL-17 enhanced the NO-dependent toxicity of proinflammatory cytokines toward MIN6 cells, while IL-17-specific neutralizing antibody partially reduced the NO production and rescued insulinoma cells and pancreatic islets from NO-dependent damage induced by activated T cells. Finally, a significant increase in blood IL-17 levels was observed in a multiple low-dose streptozotocin model of diabetes, suggesting that T cell-derived IL-17 might be involved in NO-dependent damage of beta cells in this disease. | en |
dc.description.sponsorship | null | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Cellular and Molecular Life Sciences | sr |
dc.title | Interleukin-17 stimulates inducible nitric oxide synthase-dependent toxicity in mouse beta cells | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Стошић-Грујичић, Станислава Д.; Момчиловић, Миљана Б.; Цветковић, Ивана Д.; Трајковић, Владимир С; Миљковић, Ђорђе М.; Максимовић-Иванић, Данијела Д.; | |
dc.rights.holder | © 2005, Birkhäuser Verlag, Basel | |
dc.citation.issue | 22 | sr |
dc.citation.volume | 62 | sr |
dc.identifier.doi | 10.1007/s00018-005-5259-0 | |
dc.identifier.scopus | 2-s2.0-28344439845 | |
dc.identifier.wos | 000233732900012 | |
dc.citation.spage | 2668 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1686 |