Приказ основних података о документу
Effects of extracellular calcium on fASIC1 currents
dc.creator | Todorović, Nataša | |
dc.creator | Ćorić, Tatjana | |
dc.creator | Zhang, Ping | |
dc.creator | Canessa, Cecilia | |
dc.date.accessioned | 2017-11-23T11:15:20Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2005 | sr |
dc.identifier.issn | 0077-8923 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1711 | |
dc.description.abstract | Fish ASIC1 (fASIC1) cloned from Opsanus tau, unlike the rat ASICs, requires Ca2+, in the extracellular preconditioning solution (pH 7.4) to be activated. Here we show that fASIC1 is interacting with Ca2+ in the same way as mammalian ASICs: extracellular Ca2+, is increasing the proportion of channels available for activation by stabilizing the closed state of the channel; in the activation process Ca2+ is released; H+ compete for the binding site of Ca2+ making the gating mechanism both Ca2+ and H+ dependent; H+ stabilizes the desensitized state; Ca2+ blocks the fASIC1 channel; and the affinity of the block is also modulated by H+. The "Ca2+ activation requirement" of fASICI reflects its greater affinity for steady-state desensitization by H+ compared to mammalian ASIC1. | en |
dc.language.iso | English | sr |
dc.publisher | John Wiley and Sons | |
dc.rights | restrictedAccess | |
dc.source | 22nd International Biophysics Symposium: Biophysics from Molecules to Brain: In Memory of Radoslav K. Andjus; 2004 Oct 9-14; Belgrade, Serbia | sr |
dc.title | Effects of extracellular calcium on fASIC1 currents | en |
dc.type | conferenceObject | |
dc.rights.license | ARR | |
dcterms.abstract | Тодоровић, Натаса A; Зханг, П; Цорић, Т; Цанесса, Ц; | |
dc.rights.holder | © 2009, John Wiley and Sons | |
dc.citation.issue | 1 | sr |
dc.citation.volume | 1048 | sr |
dc.description.other | 22nd International Biophysics Symposium: Biophysics from Molecules to Brain: In Memory of Radoslav K. Andjus; 2004 Oct 9-14; Belgrade, Serbia. John Wiley and Sons; 2009. p. 331-6. (Annals of the New York Academy of Sciences; Vol.10248; No. 1). | |
dc.identifier.doi | 10.1196/annals.1342.030 | |
dc.identifier.pmid | 16154945 | |
dc.identifier.scopus | 2-s2.0-25144484824 | |
dc.identifier.wos | 000233712300029 | |
dc.citation.spage | 331 | |
dc.citation.epage | 336 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1711 |