Combination of nucleoside analogues tiazofurin and ribavirin downregulates experimental autoimmune encephalomyelitis
2005
Аутори:
Lavrnja, IrenaSavić, Danijela
Peković, Sanja
Šubašić, Sanja A
Mostarica-Stojković, Marija B
Stošić-Grujičić, Stanislava
Nedeljković, Nadežda N
Medić-Mijačević, Ljubica
Rakić, Ljubisav
Stojiljković, Mirjana
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2009, John Wiley and Sons
Метаподаци
Приказ свих података о документуАпстракт:
The effect of combined treatment with ribavirin and tiazofurin on the development of experimental autoimmune encephalomyelitis, the best characterized animal model for human autoimmune disease multiple sclerosis, was investigated. The disease was induced in highly susceptible Dark Agouti rats with spinal cord homogenate in complete Freund's adjuvant. Although ribavirin or tiazofurin alone reduced the clinical and histopathological signs of experimental autoinmume encephalomyelitis, the combination of drugs achieved the same effect with significantly lower doses.
У:
- Biophysics from Molecules to Brain: In Memory of Radoslav K. John Wiley and Sons; 2009. p. 392-5. (AndjusAnnals of the New York Academy of Sciences; Vol 1048; No. 1).
DOI: 10.1196/annals.1342.047
ISSN: 0077-8923
PubMed: 16154960