Приказ основних података о документу
The role of interleukin-17 in inducible nitric oxide synthase-mediated nitric oxide production in endothelial cells
dc.creator | Miljković, Đorđe | |
dc.creator | Stojanović, Ivana D. | |
dc.creator | Vucković, Olivera | |
dc.creator | Stošić-Grujičić, Stanislava | |
dc.creator | Mostarica-Stojković, Marija B | |
dc.creator | Trajković, Vladimir S | |
dc.date.accessioned | 2017-11-23T11:15:28Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2003 | sr |
dc.identifier.issn | 1420-682X | sr |
dc.identifier.other | Rad_konverzija_3768 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1773 | |
dc.description.abstract | The effect of interleukin (IL)-17 on the activation of inducible nitric oxide (NO) synthase (iNOS) and subsequent production of NO was investigated. IL-17 induced NO production in both mouse and rat endothelial cells in a dose- and time-dependent manner. This was paralleled by the induction of mRNA for iNOS, which was markedly down-regulated by specific antagonists of protein tyrosine kinase, p38 MAP kinase or iNOS transcription factor NF-KB. The expression of iNOS transcription factor IRF-1 was also induced by IL-17 and blocked by all three inhibitors, suggesting that the induction of iNOS by IL-17 might be partly exerted through IRF-1 activation. Neutralization with the specific antibody showed that endogenous IL-17 is involved in T cell-mediated NO production in endothelial cells and NO-dependent suppression of T cell growth. These data indicate that IL-17-triggered iNOS activation in endothelial cells might participate in regulation of the T cell-dependent inflammatory response. | en |
dc.description.sponsorship | null | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Cellular and Molecular Life Sciences | sr |
dc.title | The role of interleukin-17 in inducible nitric oxide synthase-mediated nitric oxide production in endothelial cells | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Цветковић, Ивана Д.; Мостарица-Стојковић, Марија Б; Вуцковић, Оливера; Трајковић, Владимир С; Миљковић, Ђорђе М.; Стошић-Грујичић, Станислава Д.; | |
dc.citation.issue | 3 | sr |
dc.citation.volume | 60 | sr |
dc.citation.epage | 525 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1773 |
Документи
Датотеке | Величина | Формат | Преглед |
---|---|---|---|
Уз овај запис нема датотека. |