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Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium
dc.creator | Ognjanović, Branka I | |
dc.creator | Pavlović, Slađan | |
dc.creator | Maletić, Snezana D | |
dc.creator | Žikić, Radoslav V. | |
dc.creator | Stajn, Andras S | |
dc.creator | Radojičić, Ratko M. | |
dc.creator | Saičić, Zorica | |
dc.creator | Petrović, Vojislav M. | |
dc.date.accessioned | 2017-11-23T11:15:40Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2003 | sr |
dc.identifier.issn | 0862-8408 | sr |
dc.identifier.other | Rad_konverzija_3778 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1783 | |
dc.description.abstract | The effects of acute exposure to cadmium (Cd) on the blood antioxidant defense system, lipid peroxide concentration and hematological parameters, as well as the possible protective role of vitamin E were studied. Male Wistar albino rats (3 months old) were treated with cadmium (0.4 mg Cd/kg b.m., i.p., 24 h before the experiment) or with vitamin E+Cd (20 IU Vit E/kg b.m., i.m., 48 h + 0.4 mg Cd/kg b.m., i.p., 24 h before the experiment). The hematological parameters were assessed: red blood cell counts, hematocrit value and hemoglobin concentration were significantly decreased in the blood of Cd-treated rats. Intoxication with cadmium was also followed by significantly increased lipid peroxide concentrations. We also observed increased activity of antioxidant defense enzymes: copper zinc containing superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase as well as concentrations of non-enzymatic components of antioxidant defense system: reduced glutathione, vitamin C and vitamin E. Pretreatment with vitamin E exhibited a protective role on the toxic effects of cadmium on the hematological values, lipid peroxide concentration as well as on enzymatic and non-enzymatic components of antioxidant defense system. | en |
dc.description.sponsorship | null | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Physiological Research | sr |
dc.title | Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Павловић, Слађан З.; Стајн, Aндрас С; Радојичић, Ратко М.; Петровић, Војислав М.; Огњановић, Бранка И; Жикић, Радослав В.; Малетић, Снезана Д; Саичић, Зорица; | |
dc.citation.issue | 5 | sr |
dc.citation.volume | 52 | sr |
dc.citation.epage | 570 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M23 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1783 |
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