Effects of prolonged atherogenic diet on lipid status and some antioxidant parameters in rat blood

Abstract

In this study we measured the effects of eight-week atherogenic diet on plasma lipid status, glutathione-S-transferase activity, red blood cells-catalase activity, and glutathione and vitamin E plasma level adult male Wistar albino rats. The animals were sacrificed by decapitation 24 h after the end of the diet. Triglycerides, total cholesterol, and LDL cholesterol plasma levels, as well as LDL/HDL ratio, and vitamin E plasma level significantly raised (p<0,05) after the diet in comparison with the controls. HDL cholesterol plasma level, glutathione-S-transferase and red blood cells-catalase activities, and glutathione plasma level remained unchanged (p>0,05). These findings demonstrated that prolonged specific atherogenic diet in rats induced significant raise of the lipid parameters, but did not affect blood antioxidant status.