dc.creator | Samardžić, Tatjana S. | |
dc.creator | Janković, V | |
dc.creator | Stošić-Grujičić, Stanislava | |
dc.creator | Popadić, Dusan M | |
dc.creator | Trajković, Vladimir S | |
dc.date.accessioned | 2017-11-23T11:15:34Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2001 | sr |
dc.identifier.issn | 0009-9104 | sr |
dc.identifier.other | Rad_konverzija_3810 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1815 | |
dc.description.abstract | The effect of phosphodiesterase-inhibiting anti-inflammatory drug pentoxifylline (PTX) on LPS-induced IL-18 synthesis and IL-18-mediated IFN-gamma -induction were investigated. In a dose-dependent manner PTX inhibited production of IL-18 in LPS-treated cultures of murine spleen cells and bone marrow-derived macrophages. Similarly, PTX treatment significantly reduced blood IL-18 levels and expression of spleen IL-18 mRNA in LPS-challenged mice. The inhibitory effect of PTX was specific for IL-18, since LPS-induced IL-12 p40 release was not suppressed either in splenocyte cultures or blood of LPS-injected animals. Synergistic induction of IFN-gamma by combined IL-12/IL-18 treatment was also inhibited by PTX in vitro and in vivo. Experiments with IL-12 pretreatment of splenocytes, followed by IL-18 stimulation, revealed that PTX suppressed both IL-12 and IL-18 signals responsible for IFN-gamma induction. These results suggest that interference with IL-18 synthesis and IFN-gamma -inducing activity might contribute to anti-inflammatory actions of PTX. | en |
dc.description.sponsorship | null | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Clinical and Experimental Immunology | sr |
dc.title | Pentoxifylline inhibits the synthesis and IFN-gamma-inducing activity of IL-18 | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Стошић-Грујичић, Станислава Д.; Трајковић, Владимир С; Јанковић, В; Попадић, Дусан М; Самарджић, Татјана С.; | |
dc.citation.issue | 2 | sr |
dc.citation.volume | 124 | sr |
dc.citation.epage | 281 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M22 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1815 | |