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Tumor cell-specific inhibition of inducible nitric oxide synthase activation by tiazofurin
dc.creator | Samardžić, Tatjana S. | |
dc.creator | Stošić-Grujičić, Stanislava | |
dc.creator | Zogović, Nevena | |
dc.creator | Trajković, Vladimir S | |
dc.date.accessioned | 2017-11-23T11:15:35Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2001 | sr |
dc.identifier.issn | 1567-5769 | sr |
dc.identifier.other | Rad_konverzija_3812 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1817 | |
dc.description.abstract | The effects of tiazofurin (TR) on proliferation and cytokine-induced nitric oxide (NO) production in the L929 fibrosarcoma cell line and murine embryonic fibroblasts were investigated. Treatment with TR inhibited the growth of nonconfluent L929 cells in a dose-dependent manner. TR, at concentrations not affecting cell viability or proliferation, markedly decreased IFN-gamma + LPS-induced expression of inducible NO synthase (iNOS) mRNA and, subsequently. NO production in confluent L929 cultures. However, TR did not interfere with the IFN-gamma -triggered expression of mRNA for IRF-1, an important iNOS transcription factor, implying that TR interferes with some other intracellular pathway involved in iNOS induction triggered by IFN-gamma + LPS. In contrast to the results obtained in L929 cells, iNOS mRNA expression induced by IFN-gamma + LPS in murine embryonic fibroblasts was resistant to TR, indicating a tumor-selective action of this agent. (C) 2001 Elsevier Science B.V. All rights reserved. | en |
dc.description.sponsorship | null | sr |
dc.language.iso | English | sr |
dc.publisher | Elsevier | |
dc.rights | restrictedAccess | |
dc.source | International Immunopharmacology | sr |
dc.title | Tumor cell-specific inhibition of inducible nitric oxide synthase activation by tiazofurin | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Самарджић, Татјана С.; Стошић-Грујичић, Станислава Д.; Раицевић, Невена; Трајковић, Владимир С; | |
dc.rights.holder | © 2001 Elsevier Science B.V. | |
dc.citation.issue | 4 | sr |
dc.citation.volume | 1 | sr |
dc.identifier.doi | 10.1016/S1567-5769(01)00014-5 | |
dc.identifier.pmid | 11357892 | |
dc.identifier.scopus | 2-s2.0-0035103116 | |
dc.identifier.wos | 000168821800019 | |
dc.citation.spage | 795 | |
dc.citation.epage | 802 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M23 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1817 |