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STAT1 is required for iNOS activation, but not IL-6 production in murine fibroblasts
dc.creator | Samardžić, Tatjana S. | |
dc.creator | Janković, V | |
dc.creator | Stošić-Grujičić, Stanislava | |
dc.creator | Trajković, Vladimir S | |
dc.date.accessioned | 2017-11-23T11:15:35Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2001 | sr |
dc.identifier.issn | 1043-4666 | sr |
dc.identifier.other | Rad_konverzija_3815 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1820 | |
dc.description.abstract | The role of transcription factor STAT1 in production of pro-inflammatory mediators nitric oxide (NO) and IL-6 was examined in murine embryonic fibroblasts. While cells from wild-type animals released large amounts of NO after stimulation with IFN-gamma in combination with LPS, TNF-alpha or IL-1, their STAT1-deficient counterparts failed to synthesise detectable levels of this free radical gas. Inability of STAT1(-/-) fibroblasts to produce NO was accompanied by complete absence of mRNA for iNOS and its transcription factor IRF-1, both readily upregulated in wild-type cells. However, treatment with cytokines (IFN-gamma, TNF-alpha, IL-1, IL-17) significantly increased IL-6 generation in STAT1-deficient fibroblasts. These results indicate that STAT1 activation and subsequent IRF-1 transcription are required for induction of iNOS, but not IL-6 in murine fibroblasts. (C) 2001 Academic Press. | en |
dc.description.sponsorship | null | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Cytokine | sr |
dc.title | STAT1 is required for iNOS activation, but not IL-6 production in murine fibroblasts | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Јанковић, В; Самарджић, Татјана С.; Стошић-Грујичић, Станислава Д.; Трајковић, Владимир С; | |
dc.citation.issue | 3 | sr |
dc.citation.volume | 13 | sr |
dc.citation.epage | 182 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M22 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1820 |
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