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Effect of centrally administered somatostatin on pituitary thyrotropes in male rats
dc.creator | Milošević, Verica | |
dc.creator | Sekulić, Milka I. | |
dc.creator | Brkić, Branislava | |
dc.creator | Lovren, Mirjana B. | |
dc.creator | Starčević, Vesna P. | |
dc.date.accessioned | 2017-11-23T11:15:36Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2000 | sr |
dc.identifier.issn | 0018-2214 | sr |
dc.identifier.other | Rad_konverzija_3824 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1829 | |
dc.description.abstract | The effects of intracerebroventricularly administered somatostatin (SRIH-14 or -28) on growth and function of pituitary thyrotropes (TSH-cells) were examined in adult male Wistar rats. The animals were implanted with an intracerebroventricular cannula and after a recovery period, administered three 1 mug doses of SRIH-14 or -28 dissolved in 5 mul saline every second day. Controls were treated in the same way with the same volume of saline only. TSH-producing cells were studied using the peroxidase-antiperoxidase immunohistochemical procedure. Blood samples were collected for hormone (TSH) analyses 5 days after the last injection. Both SRIH-treatments significantly decreased (p < 0.05) all morphometric parameters obtained for TSH-cells in comparison with controls. The volume of TSH-cells decreased by 27%, nuclei by 44% and volume density by 33% in animals treated with SRIH-14. In animals treated with SRIH-28, these parameters were also significantly decreased (p < 0.05) (22%, 31%, and 25% respectively) compared to control rats. Serum concentrations of TSH were significantly decreased (p < 0.05) by 15% in SRIH-14- and by 12% in SRIH-28-treated animals in comparison with the controls. These observations suggest that centrally administered SRIH-14 or -28 is specifically involved in the control of growth and secretory activity of TSH cells. | en |
dc.description.sponsorship | null | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Histochemical Journal | sr |
dc.title | Effect of centrally administered somatostatin on pituitary thyrotropes in male rats | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Милошевић, Верица Љ.; Бркић, Бранислава; Старчевић, Весна П.; Ловрен, Мирјана Б.; Секулић, Милка И.; | |
dc.citation.issue | 9 | sr |
dc.citation.volume | 32 | sr |
dc.citation.epage | 569 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M23 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1829 |
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