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Effects of centrally applied somatostatin on pituitary adrenocorticotropes in female rats
dc.creator | Starcević, Vladan | |
dc.creator | Milošević, Verica | |
dc.creator | Brkić, B | |
dc.creator | Severs, Walter B | |
dc.date.accessioned | 2017-11-23T11:15:43Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2000 | sr |
dc.identifier.issn | 0031-7012 | sr |
dc.identifier.other | Rad_konverzija_3834 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1839 | |
dc.description.abstract | Effects of intracerebroventricular (i.c.v.) application of somatostatin (SRIH-14 or SRIH-28) on growth and function of pituitary adrenocorticotropes (ACTH cells) were examined in adult female Wistar rats. Animals were subjected to i.c.v. administration of three 1-mu g doses of SRIH-14 or SRIH-28 dissolved in 5 mu l saline every second day, Controls were treated in the same way with the same volume of saline only, ACTH-producing cells were studied using the peroxidase-anti peroxidase (PAP) immunohistochemical procedure; blood samples were collected for hormone analyses 5 days after the last injection, SRIH-28 treatment decreased (p < 0.05) all morphometric parameters compared to control rats. Volume of ACTH cells decreased by 10%, nuclei by 36% and volume density by 13%, No significant changes (p > 0.05) in these para meters occurred after SRIH-14 treatment. Plasma concentration of ACTH in SRIH-28-treated rats was significantly lower (p < 0.05) than in control rats by 35%. In SRIH-14-treated rats, plasma concentration of ACTH was slightly, but not significantly (p > 0.05) increased by 13% compared to saline treatment. These observations suggest that centrally administered somatostatin-28, but not somatostatin-14, is specifically involved in the control of growth and secretory activity of ACTH cells in female rats, Thus, selective pharmacological manipulation of SRIH-28 receptors reached from CSF may affect ACTH activity without altering actions usually attributed to receptors sensitive to SRIF-14. Copyright (C) 2000 S. Karger AG, Basel. | en |
dc.description.sponsorship | null | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Pharmacology | sr |
dc.title | Effects of centrally applied somatostatin on pituitary adrenocorticotropes in female rats | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Северс, Wалтер Б; Старцевић, Владан; Милошевић, Верица Љ.; Бркић, Б; | |
dc.citation.issue | 4 | sr |
dc.citation.volume | 60 | sr |
dc.citation.epage | 207 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M23 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1839 |
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