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The effect of IL-1 receptor antagonist on the proliferation of hematopoietic progenitor cells in regenerating bone marrow
dc.creator | Jovcić, G | |
dc.creator | Ivanović, Z | |
dc.creator | Biljanović-Paunović, L | |
dc.creator | Bugarski, D | |
dc.creator | Stošić-Grujičić, Stanislava | |
dc.creator | Milenković, P | |
dc.date.accessioned | 2017-11-23T11:15:51Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 1996 | sr |
dc.identifier.issn | 0887-6924 | sr |
dc.identifier.other | Rad_konverzija_3889 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1894 | |
dc.description.abstract | To evaluate the involvement of IL-1 on bone marrow granulocyte-macrophage (CFU-GM) and erythroid (BFU-E and CFU-E) progenitor cell regeneration during the recovery of hematopoiesis after sublethal irradiation of CBA mice, we examined the effects of IL-1 receptor blockade by recombinant human IL-1 receptor antagonist (rhIL-1ra). The actual number of progenitors and proportion of these cells in S phase of the cell cycle were determined in regenerating bone marrow cells obtained 3 days after 2 Gy irradiation both following the in vivo administration of rhIL-1ra, as well as after the in vitro preincubation with increasing amounts of rhIL-1ra. The results revealed that rhIL-1ra decreased the number and the proportion of CFU-GM in the S phase in regenerating bone marrow. As concerning erythroid progenitors, rhIL-1ra treatment suppressed BFU-E and enhanced CFU-E-derived colony growth, indicating that the biological effects of IL-1 might be different depending on the stage of differentiation. The observed effects pointed to the importance of the basal levels of IL-1, as well as IL-1 receptor expression during the recovery of hematopoiesis. | en |
dc.description.sponsorship | null | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Leukemia | sr |
dc.title | The effect of IL-1 receptor antagonist on the proliferation of hematopoietic progenitor cells in regenerating bone marrow | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Миленковић, П; Биљановић-Пауновић, Л; Јовцић, Г; Бугарски, Д; Стошић-Грујичић, Станислава Д.; Ивановић, З; | |
dc.citation.issue | 3 | sr |
dc.citation.volume | 10 | sr |
dc.citation.epage | 569 | sr |
dc.type.version | publishedVersion | en |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1894 |
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