Age-related disorders of sleep and motor control in the rat models of functionally distinct cholinergic neuropathology
2016
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Чланак у часопису (Објављена верзија)
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Приказ свих података о документуАпстракт:
We studied the impact of aging during sleep in the rat models of
Alzheimer's (AD) and Parkinson's (PD) disease cholinergic neuropathology
to determine the possible different and earlier onset of age-related
sleep disorder during the neurodegenerative diseases vs. healthy aging.
We used the bilateral nucleus basalis (NB) and pedunculopontine
tegmental nucleus (PPT) lesioned rats as the in vivo models of
functionally distinct cholinergic neuropathology, and we followed the
impact of aging on sleep architecture, the electroencephalographic (EEG)
microstructure and motor control across sleep/wake states.
Our results have shown for the first time that the earliest signs of
aging during distinct cholinergic neuropathology were expressed through
a different and topographically specific EEG microstructure during rapid
eye movement sleep (REM). EEG delta amplitude attenuation within the
sensorimotor cortex (SMCx) during REM was the earliest sign of aging in
the NB lesion. EEG sigma amplitude augmentation within the motor cortex
(MCx) during REM was the earliest sign of aging in the PPT lesion. In
addition, aging was differently expressed through the SMCx drive
alterations, but it was commonly expressed through the MCx drive
alterations during all sleep/wake states.
Our study provided evidence of distinct REM sleep disorders and sleep
state related cortical drives as the signs of aging onset during
functionally distinct cholinergic neuropathologies (NB lesion vs. PPT
lesion). (C) 2015 Elsevier B.V. All rights reserved.
Кључне речи:
Aging; Sleep; Cortical drive; The pedunculopontine tegmental nucleus; The nucleus basalis; Cholinergic neuronal lossИзвор:
Behavioural Brain Research, 2016, 301, 273-286
DOI: 10.1016/j.bbr.2015.12.046
ISSN: 1872-7549