The expression and activity of antioxidant enzymes in the liver of rats exposed to high-fructose diet in the period from weaning to adulthood
2015
Аутори:
Glban, Alhadi M.Teofilović, Ana
Velickovic, Natasa
Nikolić-Kokić, Aleksandra
Blagojević, Duško
Matić, Gordana
Brkljačić, Jelena
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
BACKGROUNDIncreased fructose consumption correlates with rising
prevalence of various metabolic disorders, some of which were linked to
oxidative stress. The relationship between fructose consumption and
oxidative stress is complex and effects of a fructose-rich diet on the
young population have not been fully elucidated. The aim of this study
was to investigate whether high-fructose diet applied in the period from
weaning to adulthood induces oxidative stress in the liver, thus
contributing to induction or aggravation of metabolic disturbances in
later adulthood. To that end we examined the effects of high-fructose
diet on expression and activity of antioxidant enzymes, markers of lipid
peroxidation and protein damage in the liver as the main fructose
metabolizing tissue.
RESULTSHigh-fructose diet increased only SOD2 (mitochondrial manganese
superoxide dismutase) activity, with no effect on other antioxidant
enzymes, lipid peroxidation or accumulation of damaged proteins in the
liver.
CONCLUSIONThe results show that fructose-induced metabolic disturbances
could not be attributed to oxidative stress, at least not at young age.
The absence of oxidative stress in the liver observed herein implies
that young organisms are capable of maintaining redox homeostasis when
challenged by fructose-derived energy overload. (c) 2014 Society of
Chemical Industry
Кључне речи:
antioxidant enzymes; fructose-fed rat; liver; oxidative stress; young ratИзвор:
Journal of the Science of Food and Agriculture, 2015, 95, 11, 2319-2324
DOI: 10.1002/jsfa.6953
ISSN: 1097-0010