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Effects of 5-Fluorouracil, Etoposide and CdCl2 in Aquatic Oligochaeta Limnodrilus udekemianus Claparede (Tubificidae) Measured by Comet Assay
dc.creator | Kračun-Kolarević, Margareta | |
dc.creator | Kolarević, Stoimir | |
dc.creator | Atanacković, Ana | |
dc.creator | Marković, Vanja | |
dc.creator | Gačić, Zoran | |
dc.creator | Paunović, Momir | |
dc.creator | Vuković-Gačić, Branka | |
dc.date.accessioned | 2017-11-23T11:28:18Z | |
dc.date.available | 2017-11-23T11:28:18Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1573-2932 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1933 | |
dc.identifier.uri | http://link.springer.com/article/10.1007%2Fs11270-015-2511-6 | |
dc.description.abstract | Genotoxicity of 5-fluorouracil (5-FU), etoposide (ET) and cadmium chloride (CdCl2) was evaluated in Limnodrilus udekemianus, cosmopolitan tubificid species, by alkaline single-cell gel electrophoresis (comet assay). Groups of 50 individuals were exposed in vivo in water-only short-term (96 h) tests to 5-FU (0.004, 0.04, 0.4, 4 and 40 mu M), ET (0.004. 0.04, 0.4 and 4 mu M) and CdCl2 (0.004, 0.04, 0.4, 4 and 40 mu M). Mortality of worms was observed only for CdCl2 (4 and 40 mu M). Cell viability lower than 70 \% was detected for 5-FU (0.4, 4 and 40 mu M), ET (4 mu M) and CdCl2 (0.4 and 4 mu M). All tested substances induced significant increase of DNA damage except 0.004 mu M of ET. L. udekemianus being sensitive to all tested substances indicates that it can be used in ecogenotoxicology studies. Concern should be raised to cytostatics, especially to 5-FU, since concentration of 0.004 mu M induced DNA damage is similar to ones detected in wastewaters. | en |
dc.language | English | |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/265264/EU// | |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/603629/EU// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/37009/RS// | |
dc.rights | restrictedAccess | |
dc.source | Water Air and Soil Pollution | |
dc.subject | Limnodrilus udekemianus | |
dc.subject | 5-Fluorouracil | |
dc.subject | Etoposide | |
dc.subject | CdCl2 | |
dc.subject | Genotoxicity | |
dc.subject | Comet assay | |
dc.title | Effects of 5-Fluorouracil, Etoposide and CdCl2 in Aquatic Oligochaeta Limnodrilus udekemianus Claparede (Tubificidae) Measured by Comet Assay | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Aтанацковић, Aна Д.; Коларевић, Стоимир; Гачић, Зоран; Вуковић-Гачић, Бранка; Пауновић, Момир; Марковић, Вања; Крачун-Коларевић, Маргарета; | |
dc.rights.holder | © Springer International Publishing Switzerland 2015 | |
dc.citation.issue | 242 | |
dc.citation.volume | 226 | |
dc.description.other | Water Air and Soil Pollution (2015), 226(242) | |
dc.identifier.doi | 10.1007/s11270-015-2511-6 | |
dc.identifier.pmid | 27546921 | |
dc.identifier.scopus | 2-s2.0-84958057878 | |
dc.identifier.wos | 000359369600022 | |
dc.citation.apa | Kračun-Kolarević, M., Kolarević, S., Atanacković, A., Marković, V., Gačić, Z., Paunović, M., & Vuković-Gačić, B. (2015). Effects of 5-Fluorouracil, Etoposide and CdCl2 in Aquatic Oligochaeta Limnodrilus udekemianus Claparede (Tubificidae) Measured by Comet Assay. Water, Air, & Soil Pollution, 226(8), 242. Springer International Publishing. | |
dc.citation.apa | Kračun-Kolarević M, Kolarević S, Atanacković A, Marković V, Gačić Z, Paunović M, Vuković-Gačić B. Effects of 5-Fluorouracil, Etoposide and CdCl2 in Aquatic Oligochaeta Limnodrilus udekemianus Claparede (Tubificidae) Measured by Comet Assay. Water Air Soil Pollut. 2015;226(8):242. | |
dc.type.version | publishedVersion | en |