Tumor necrosis factor stimulates expression of CXCL12 in astrocytes
2015
Аутори:
Blaževski, JanaPetković, Filip
Momčilović, Miljana
Jevtić, Bojan
Stojkovic, Marija Mostarica
Miljković, Đorđe
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
It has been increasingly appreciated that tumor necrosis factor (TNF)
performs various protective and anti-inflammatory functions in multiple
sclerosis (MS) and its animal model experimental autoimmune
encephalomyelitis (EAE). Recently, CXCL12 has been identified as a key
inhibitor of leukocyte entry into the central nervous system (CNS) and
as a regulator of inflammation resulting from the invasion. Here, a
positive correlation between expression of TNF and CXCL12 in the CNS
samples of EAE rats is presented. Also, it is shown that TNF potentiates
CXCL12 expression in astrocytes. These results contribute to a view that
TNF produced within the CNS plays a protective role in
neuroinflammation. (C) 2015 Elsevier GmbH. All rights reserved.
Кључне речи:
Experimental autoimmune encephalomyelitis; Tumor necrosis factor; Astrocyte; NeuroinflammationИзвор:
Immunobiology, 2015, 220, 7, 845-850
DOI: 10.1016/j.imbio.2015.01.007
ISSN: 0171-2985