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Tumor necrosis factor stimulates expression of CXCL12 in astrocytes
dc.creator | Blaževski, Jana | |
dc.creator | Petković, Filip | |
dc.creator | Momčilović, Miljana | |
dc.creator | Jevtić, Bojan | |
dc.creator | Stojkovic, Marija Mostarica | |
dc.creator | Miljković, Đorđe | |
dc.date.accessioned | 2016-05-23T10:59:43Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0171-2985 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1937 | |
dc.description.abstract | It has been increasingly appreciated that tumor necrosis factor (TNF) performs various protective and anti-inflammatory functions in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Recently, CXCL12 has been identified as a key inhibitor of leukocyte entry into the central nervous system (CNS) and as a regulator of inflammation resulting from the invasion. Here, a positive correlation between expression of TNF and CXCL12 in the CNS samples of EAE rats is presented. Also, it is shown that TNF potentiates CXCL12 expression in astrocytes. These results contribute to a view that TNF produced within the CNS plays a protective role in neuroinflammation. (C) 2015 Elsevier GmbH. All rights reserved. | en |
dc.description.sponsorship | Ministry of Education, Science and Technological Development of the Republic of Serbia {[}173035, 175038, 173013] | |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Immunobiology | |
dc.subject | Experimental autoimmune encephalomyelitis | |
dc.subject | Tumor necrosis factor | |
dc.subject | Astrocyte | |
dc.subject | Neuroinflammation | |
dc.title | Tumor necrosis factor stimulates expression of CXCL12 in astrocytes | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Јевтић, Бојан; Петковић, Филип; Миљковић, Ђорђе М.; Момчиловић, Миљана Б.; Блажевски, Јана; Стојковиц, Марија Мостарица; | |
dc.citation.issue | 7 | |
dc.citation.volume | 220 | |
dc.identifier.doi | 10.1016/j.imbio.2015.01.007 | |
dc.identifier.scopus | 2-s2.0-84929507535 | |
dc.identifier.wos | 000356317000001 | |
dc.citation.spage | 845 | |
dc.citation.epage | 850 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M22 |