Positive effects of naringenin on near-surface membrane fluidity in human erythrocytes
2015
Аутори:
Ajdžanović, VladimirJakovljevic, V.
Milenkovic, D.
Konic-Ristic, A.
Zivanovic, J.
Jaric, I.
Milosevic, V.
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Purpose: Deformability/rheologic behavior of erythrocytes are related to
near-surface membrane fluidity. Specific agents can increase erythrocyte
membrane fluidity in order to adjust hemodynamics in cardiovascular
diseases. Grapefruit flavanone naringenin has been proposed for
potential use in an alternative therapy of cardiovascular conditions. In
respect to this, we assessed here effects of two nutritionally relevant
concentrations of naringenin (0.1 and 1 mu g/ml) on near-surface
membrane fluidity in human erythrocytes. Methods: We used electron
paramagnetic resonance spectroscopy and fatty acid spin probes (5-DS and
7-DS), the spectra of which are dependent on membrane fluidity. Results:
The results showed a significant (p = 0.029) increase of membrane
fluidity near the hydrophilic surface in erythrocytes treated with
higher concentration of naringenin. In the deeper layer, just below the
erythrocyte membrane phospholipid heads, both lower and higher
concentration of naringenin significantly increased membrane fluidity (p
= 0.036 and p = 0.028, respectively). Conclusions: These data document
the positive and dose dependent effect of naringenin on near-surface
membrane fluidity in human erythrocytes, recommending its use in the
cardiovascular conditions characterized by disturbed hemodynamics.
Кључне речи:
naringenin; membrane fluidity; erythrocytes; cardiovascularИзвор:
Acta Physiologica Hungarica, 2015, 102, 2, 131-136
DOI: 10.1556/036.102.2015.2.3
ISSN: 1588-2683