Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities
2015
Authors:
Ferreira, Isabel C. F. R.Heleno, Sandrina A.
Reis, Filipa S.
Stojković, Dejan
Queiroz, Maria Joao R. P.
Helena Vasconcelos, M.
Soković, Marina
Document Type:
Review (Published version)
,
© 2014 Elsevier Ltd
Metadata
Show full item recordAbstract:
Ganoderma genus comprises one of the most commonly studied species
worldwide, Ganoderma lucidum. However, other Ganoderma species have been
also reported as important sources of bioactive compounds.
Polysaccharides are important contributors to the medicinal properties
reported for Ganoderma species, as demonstrated by the numerous
publications, including reviews, on this matter. Yet, what are the
chemical features of Ganoderma polysaccharides that have bioactivity? In
the present manuscript, the chemical features of Ganoderma
polysaccharides with reported antioxidant, antitumor and antimicrobial
activities (the most studied worldwide) are analyzed in detail. The
composition of sugars (homo- versus hetero-glucans and other
polysaccharides), type of glycosidic linkages, branching patterns, and
linkage to proteins are discussed. Methods for extraction, isolation and
identification are evaluated and, finally, the bioactivity of
polysaccharidic extracts and purified compounds are discussed. The
integration of data allows deduction of structure-activity relationships
and gives clues to the chemical aspects involved in Ganoderma
bioactivity. (C) 2014 Elsevier Ltd. All rights reserved.
Keywords:
Ganoderma; Polysaccharides; Chemical features; Bioactivity; Structure-activitySource:
Phytochemistry, 2015, 114, SI, 38-55
DOI: 10.1016/j.phytochem.2014.10.011
ISSN: 0031-9422
PubMed: 25457487