Joint effect of ADARB1 gene, HTR2C gene and stressful life events on suicide attempt risk in patients with major psychiatric disorders
2015
Autori:
Karanovic, JelenaSvikovic, Sasa
Pantovic, Maja
Durica, Svetlana
Brajuskovic, Goran
Damjanovic, Aleksandar
Jovanović, Vladimir
Ivkovic, Maja
Romac, Stanka
Pavicevic, Dusanka Savic
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Objectives. Adenosine to inosine RNA editing, serotonin 2C receptor
(HTR2C), and stressful life events (SLEs) have all been implicated in
suicidal behaviour. We examined the main and moderating effects of RNA
editing (ADAR, ADARB1) and HTR2C genes, childhood trauma (CT), recent
SLEs and psychiatric disorders as contributors to suicide attempt (SA)
vulnerability. Methods. Study included 165 suicide attempters and 188
suicide non-attempters, all diagnosed with one of major psychiatric
disorders. CT and recent SLEs were assessed using Early Trauma
Inventory-Self Report and List of Threatening Experiences Questionnaire,
respectively. Selected ADAR and ADARB1 tag-variants, and HTR2C rs6318
were pre-screened for association with SA, while generalized linear
models and backward selection were applied to identify individual and
interacting SA risk factors. Results. ADARB1 rs9983925 and rs4819035 and
HTR2C rs6318 were associated with SA. The best minimal model found
emotional abuse, recent SLEs, rs9983925 and rs6318 as independent SA
risk factors, and general traumas as a factor moderating the effect of
psychiatric disorders and emotional abuse. Conclusions. SA vulnerability
in psychiatric patients is related to the joint effect of ADARB1 and
HTR2C variants, the existing mood disorder and the cumulative exposures
to a various childhood and recent stressful experiences.
Ključne reči:
suicide attempted; serotonin 2C receptor; stressful events; risk factorsIzvor:
World Journal of Biological Psychiatry, 2015, 16, 4, 261-271
DOI: 10.3109/15622975.2014.1000374
ISSN: 1814-1412