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Anti-diabetic actions of carbon monoxide-releasing molecule (CORM)-A1: Immunomodulation and regeneration of islet beta cells
dc.creator | Nikolić, Ivana | |
dc.creator | Saksida, Tamara | |
dc.creator | Vujičić, Milica | |
dc.creator | Stojanović, Ivana D. | |
dc.creator | Stošić-Grujičić, Stanislava | |
dc.date.accessioned | 2016-05-23T10:59:46Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1879-0542 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1962 | |
dc.description.abstract | We have recently shown that carbon monoxide releasing molecule (CORM)-A1 prevents type 1 diabetes induced in C57BL/6 mice with multiple low doses of streptozotocin (MLDS) by shifting the Th1/Th17/M1 balance towards a Th2/M2 response. In the present work we tested the hypothesis that CORM-A1 might influence regulatory arm of the immune response, as well as beta cell regeneration. CORM-A1 (2 mg/kg/day) was administered for 10 days to mice induced with MLDS and/or depleted of low dose cyclophosphamide (CY)-sensitive FoxP3(+) T regulatory (Treg) cells. Besides monitoring hyperglycaemia, ex vivo analysis of spleen, pancreatic lymph nodes (PLN) and pancreas was performed at the end of treatment. In CORM-A1-treated MLDS-induced mice the improvement of hyperglycaemia was observed only without depletion of CY-sensitive FoxP3(+) Treg cells. This was accompanied by decreased levels of interleukin (IL)-12, IL-2 and early activation marker CD25 in the spleen and PLN and increased transforming growth factor (TGF)-beta, resulting in reduced lymphocyte proliferation in both organs. In parallel, decreased transcript levels of IL-2, but increased mRNA expression of TGF-beta, accompanied with up-regulation of Ki-67 protein expression was observed within pancreas. Together, the data suggested that besides the immunomodulatory potential, CORM-A1 probably induces beta cell regeneration. (C) 2015 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved. | en |
dc.description.sponsorship | Ministry of Education, Science and Technological Development {[}173013]; EFSD New Horizons Collaborative Research Initiative | |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Immunology Letters | |
dc.subject | Carbon monoxide-releasing molecule A1 | |
dc.subject | Lymphocytes | |
dc.subject | Cytokines | |
dc.subject | Islets of Langerhans | |
dc.subject | Type 1 diabetes | |
dc.title | Anti-diabetic actions of carbon monoxide-releasing molecule (CORM)-A1: Immunomodulation and regeneration of islet beta cells | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Вујичић, Милица; Николић, Ивана; Стојановиц, Ивана; Саксида, Тамара; Стошић-Грујичић, Станислава Д.; | |
dc.citation.issue | 1 | |
dc.citation.volume | 165 | |
dc.identifier.doi | 10.1016/j.imlet.2015.03.009 | |
dc.identifier.scopus | 2-s2.0-84926432165 | |
dc.identifier.wos | 000355035400006 | |
dc.citation.spage | 39 | |
dc.citation.epage | 46 | |
dc.type.version | publishedVersion | en |
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