Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats
2016
Аутори:
Dejanovic, BratislavStevanovic, Ivana
Ninkovic, Milica
Stojanovic, Ivana
Lavrnja, Irena
Radicevic, Tatjana
Pavlovic, Milos
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
This study was conducted to investigate whether agmatine (AGM) provides
protection against oxidative stress induced by treatment with
chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive
oxygen species and efficiency of antioxidant protection in the brain
homogenates of forebrain cortexes prepared 48 h after treatment were
investigated. Chlorpromazine was applied intraperitoneally (i.p.) in
single dose of 38.7 mg/kg body weight (BW) The second group was treated
with both CPZ and AGM (75 mg/kg BW). The control group was treated with
0.9\% saline solution in the same manner. All tested compounds were
administered i.p. in a single dose. Rats were sacrificed by decapitation
48 h after treatment Treatment with AGM significantly attenuated the
oxidative stress parameters and restored antioxidant capacity in the
forebrain cortex. The data indicated that i.p. administered AGM exerted
antioxidant action in CPZ-treated animals. Moreover, reactive astrocytes
and microglia may contribute to secondary nerve-cell damage and
participate in the balance of destructive vs. protective actions
involved in the pathogenesis after poisoning.
Кључне речи:
Agmatine; antioxidant defense; astrocytes; chlorpromazine; oxidative stressИзвор:
Journal of Veterinary Science, 2016, 17, 1, 53-61
DOI: 10.4142/jvs.2016.17.1.53
ISSN: 1976-555X