Possible involvement of glucocorticoids in 5 alpha-dihydrotestosterone-induced PCOS-like metabolic disturbances in the rat visceral adipose tissue
2015
Аутори:
Radovanović, MarinaMacut, Đuro
Đorđević, Ana
Veličković, Nataša
Nestorović, Nataša
Bursać, Biljana
Božić-Antić, Ivana
Bjekić Macut, Jelica
Matić, Gordana
Vojnović-Milutinović, Danijela
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2014 Elsevier Ireland Ltd.
Метаподаци
Приказ свих података о документуАпстракт:
Polycystic ovary syndrome (PCOS) is a reproductive and metabolic
disorder characterized by hyperandrogenism, ovulatory dysfunction,
visceral obesity and insulin resistance. We hypothesized that changes in
glucocorticoid metabolism and signaling in the visceral adipose tissue
may contribute to disturbances of lipid metabolism in the rat model of
PCOS obtained by 5 alpha-dihydrotestosterone (DHT) treatment of
prepubertal female Wistar rats. The results confirmed that DHT treatment
caused anovulation, obesity and dyslipidemia. Enhanced glucocorticoid
prereceptor metabolism, assessed by elevated intracellular
corticosterone and increased 11 beta-hydroxysteroid dehydrogenase type 1
mRNA and protein levels, was accompanied by glucocorticoid receptor (GR)
nuclear accumulation. In concert with the increased expression of
GR-regulated prolipogenic genes (lipin-1, sterol regulatory element
binding protein 1, fatty acid synthase, phosphoenolpyruvate
carboxykinase), histological analyses revealed hypertrophic adipocytes.
The results suggest that glucocorticoids influence lipid metabolism in
the visceral adipose tissue in the way that may contribute to
pathogenesis of metabolic disturbances associated with PCOS. (C) 2014
Elsevier Ireland Ltd. All rights reserved.
Кључне речи:
5 alpha-dihydrotestosterone; Visceral adipose tissue; Glucocorticoids; LipogenesisИзвор:
Molecular and Cellular Endocrinology, 2015, 399, C, 22-31Финансирање / пројекти:
- Улога стероидних хормона у неуроендокриној адаптацији на стрес и патофизиологији метаболичког синдрома - молекуларни механизми и клиничке импликације (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41009)
DOI: 10.1016/j.mce.2014.08.013
ISSN: 0303-7207
PubMed: 25179821
WoS: 000348877700003
Scopus: 2-s2.0-84908565102
URI
https://radar.ibiss.bg.ac.rs/handle/123456789/2022https://www.sciencedirect.com/science/article/pii/S0303720714002706?via%3Dihub#ac0010