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Possible involvement of glucocorticoids in 5 alpha-dihydrotestosterone-induced PCOS-like metabolic disturbances in the rat visceral adipose tissue
dc.creator | Radovanović, Marina | |
dc.creator | Macut, Đuro | |
dc.creator | Đorđević, Ana | |
dc.creator | Veličković, Nataša | |
dc.creator | Nestorović, Nataša | |
dc.creator | Bursać, Biljana | |
dc.creator | Božić-Antić, Ivana | |
dc.creator | Bjekić Macut, Jelica | |
dc.creator | Matić, Gordana | |
dc.creator | Vojnović-Milutinović, Danijela | |
dc.date.accessioned | 2016-05-23T10:59:57Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0303-7207 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2022 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0303720714002706?via%3Dihub#ac0010 | |
dc.description.abstract | Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder characterized by hyperandrogenism, ovulatory dysfunction, visceral obesity and insulin resistance. We hypothesized that changes in glucocorticoid metabolism and signaling in the visceral adipose tissue may contribute to disturbances of lipid metabolism in the rat model of PCOS obtained by 5 alpha-dihydrotestosterone (DHT) treatment of prepubertal female Wistar rats. The results confirmed that DHT treatment caused anovulation, obesity and dyslipidemia. Enhanced glucocorticoid prereceptor metabolism, assessed by elevated intracellular corticosterone and increased 11 beta-hydroxysteroid dehydrogenase type 1 mRNA and protein levels, was accompanied by glucocorticoid receptor (GR) nuclear accumulation. In concert with the increased expression of GR-regulated prolipogenic genes (lipin-1, sterol regulatory element binding protein 1, fatty acid synthase, phosphoenolpyruvate carboxykinase), histological analyses revealed hypertrophic adipocytes. The results suggest that glucocorticoids influence lipid metabolism in the visceral adipose tissue in the way that may contribute to pathogenesis of metabolic disturbances associated with PCOS. (C) 2014 Elsevier Ireland Ltd. All rights reserved. | en |
dc.language | English | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41009/RS// | |
dc.rights | restrictedAccess | |
dc.source | Molecular and Cellular Endocrinology | |
dc.subject | 5 alpha-dihydrotestosterone | |
dc.subject | Visceral adipose tissue | |
dc.subject | Glucocorticoids | |
dc.subject | Lipogenesis | |
dc.title | Possible involvement of glucocorticoids in 5 alpha-dihydrotestosterone-induced PCOS-like metabolic disturbances in the rat visceral adipose tissue | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.rights.license | restrictedAccess | |
dc.rights.holder | © 2014 Elsevier Ireland Ltd. | |
dc.citation.issue | C | |
dc.citation.volume | 399 | |
dc.identifier.doi | 10.1016/j.mce.2014.08.013 | |
dc.identifier.pmid | 25179821 | |
dc.identifier.scopus | 2-s2.0-84908565102 | |
dc.identifier.wos | 000348877700003 | |
dc.citation.apa | Nikolić, M., Macut, D., Djordjevic, A., Veličković, N., Nestorović, N., Bursać, B., et al. (2015). Possible involvement of glucocorticoids in 5α-dihydrotestosterone-induced PCOS-like metabolic disturbances in the rat visceral adipose tissue. Molecular and Cellular Endocrinology, 399, 22–31. | |
dc.citation.vancouver | Nikolić M, Macut D, Djordjevic A, Veličković N, Nestorović N, Bursać B, Antić IB, Macut JB, Matić G, Vojnović Milutinović D. Possible involvement of glucocorticoids in 5α-dihydrotestosterone-induced PCOS-like metabolic disturbances in the rat visceral adipose tissue. Mol Cell Endocrinol. 2015;399:22–31. | |
dc.citation.spage | 22 | |
dc.citation.epage | 31 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 |