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Effect of aspartame on biochemical and oxidative stress parameters in rat blood

2015
Full text (395.7Kb)
Authors:
Prokić, Marko
Paunović, Milica G.
Matić, Miloš M.
Đorđević, Nataša Z.
Ognjanović, Branka I.
Štajn, Andraš Š.
Saičić, Zorica
Document Type:
Article (Published version)
,
© 2015 by the Serbian Biological Society
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Abstract:
Aspartame (ASP) is one of the most widely used nonnutritive sweeteners. This study investigates the chronic effects of ASP on hematological and biochemical parameters, and its effects on the oxidative/antioxidative status in the red blood cells of Wistar albino rats. Rats were provided with ASP (40 mg/kg/daily for six weeks) in drinking water. Increased food and fluid intake was observed in the ASP-treated rats. Total body mass was significantly decreased in the ASP-treated rats. Treatment with ASP caused an increase in the concentrations of glucose, cholesterol, LDL-cholesterol, and in the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH), as well as a decrease in the levels of HDL-cholesterol in the serum. A significant decline in the number of white blood cells (WBC) was observed after ASP uptake. Based on the results we conclude that ASP induces oxidative stress, observed as an alteration of the glutathione redox status, which leads to increased concentrations of nitric oxide (NO) and lipid peroxides (LPO) in the red blood cells. Changes in biochemical parameters, lipid metabolism, as well as changes in the levels of oxidative stress markers and the appearance of signs of liver damage indicate that chronic use of ASP can lead to the development of hyperglycemia, hypercholesterolemia and associated diseases.
Keywords:
Aspartame; hematological parameters; biochemical parameters; oxidative stress; appetite
Source:
Archives of Biological Sciences, 2015, 67, 2, 535-545
Funding / projects:
  • Molecular and physiological biomonitoring of aerobic organisms based on the determination of biochemical biomarkers of oxidative stress (RS-173041)

DOI: 10.2298/ABS141009016P

ISSN: 1821-4339

WoS: 000358291600018

Scopus: 2-s2.0-84937408881
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URI
https://radar.ibiss.bg.ac.rs/handle/123456789/2054
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