Predictors of Subclinical Cardiovascular Disease in Women with Polycystic Ovary Syndrome: Interrelationship of Dyslipidemia and Arterial Blood Pressure
2015
Authors:
Macut, ĐuroBačević, Marina
Božić-Antić, Ivana
Bjekić-Macut, Jelica
Civcic, Milorad
Erceg, Snježana
Vojnović-Milutinović, Danijela
Stanojlović, Olivera
Andrić, Zoran
Kastratović-Kotlica, Biljana
Sukilović, Tijana
Document Type:
Article (Published version)
Metadata
Show full item recordAbstract:
Background. Women with polycystic ovary syndrome (PCOS) could develop
subclinical atherosclerosis during life. Purpose. To analyze
cardiovascular risk (CVR) factors and their relation to clinical markers
of cardiovascular disease (CVD) in respect to their age. Material and
Methods. One hundred women with PCOS (26.32 +/- 5.26 years, BMI: 24.98
+/- 6.38 kg/m(2)) were compared to 50 respective controls. In all
subjects, total cholesterol (TC), HDL-C, LDL-C, triglycerides, TC/HDL-C
and TG/HDL-C ratios, glucose, insulin and HOMA index, waist-to-hip ratio
(WHR), systolic and diastolic blood pressure (SBP and DBP, resp.), and
carotid intima-media thickness (CIMT) were analyzed in respect to their
age and level of androgens. Results. PCOS over 30 years had higher WHR
(P = 0.008), SBP (P < 0.001), DBP (P < 0.001), TC (P = 0.028), HDL-C (P
= 0.028), LDL-C (P = 0.045), triglycerides (P < 0.001), TC/HDL-C (P <
0.001), and triglycerides/HDL-C (P < 0.001) and had more prevalent
hypertension and pronounced CIMT on common carotid arteries even after
adjustment for BMI (P = 0.005 and 0.036, resp.). TC/ HDL-C and TG/HDL-C
were higher in PCOS with the highest quintile of FAI in comparison to
those with lower FAI (P = 0.045 and 0.034, resp.). Conclusions. PCOS
women older than 30 years irrespective of BMI have the potential for
early atherosclerosismirrored through the elevated lipids/lipid ratios
and through changes in blood pressure.
Source:
International Journal of Endocrinology, 2015, 812610Funding / projects:
- The development of animal models of epilepsy and testing convulsive and anticonvulsive substances (RS-MESTD-Basic Research (BR or ON)-175032)
- Role of steroid hormones in neuroendocrine adaptation to stress and pathophysiology of metabolic syndrome - molecular mechanisms and clinical implications (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41009)
DOI: 10.1155/2015/812610
ISSN: 1687-8345