Prooxidative effects of aspartame on antioxidant defense status in erythrocytes of rats
2014
Аутори:
Prokić, MarkoPaunovic, Milica G.
Matic, Milos M.
Djordjevic, Natasa Z.
Ognjanovic, Branka I.
Štajn, Andraš Š.
Saičić, Zorica
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Since aspartame (L-aspartyl-L-phenylalanine methyl ester, ASP) is one of
the most widely used artificial sweeteners, the aim of the present study
was to investigate its effects on serum glucose and lipid levels as well
as its effects on oxidative/antioxidative status in erythrocytes of
rats. The experiment included two groups of animals: the control group
was administered with water only, while the experimental group was
orally administered with ASP (40 mg/kg b.w.) daily, for a period of six
weeks. When compared with the control group, the group administrated
with ASP indicated higher values of serum glucose, cholesterol and
triglycerides. Significantly increased concentrations of superoxide
anion (O-2(center dot-)), hydrogen peroxide (H2O2), peroxynitrite
(ONOO-) and lipid peroxides (LPO) were recorded in the erythrocytes of
ASP treated group in comparison to the control group. In the course of
chronic ASP administration, the following was observed: the
concentration of reduced glutathione (GSH) and the activity of catalase
(CAT) increased. Thus, these findings suggest that long-term consumption
of ASP leads to hyperglycemia and hyperlipidemia, as well as to
oxidative stress in erythrocytes.
Кључне речи:
Antioxidative defense system; aspartame; erythrocytes; oxidative stress; ratИзвор:
Journal of Biosciences, 2014, 39, 5, 859-866
DOI: 10.1007/s12038-014-9487-z
ISSN: 0973-7138