Приказ основних података о документу
Saquinavir-NO Inhibits IL-6 Production in Macrophages
dc.creator | Momčilović, Miljana | |
dc.creator | Mangano, Katia | |
dc.creator | Jevtić, Bojan | |
dc.creator | Mammana, Santa | |
dc.creator | Stošić-Grujičić, Stanislava | |
dc.creator | Nicoletti, Ferdinando | |
dc.creator | Miljković, Đorđe | |
dc.date.accessioned | 2016-05-23T11:00:16Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1742-7843 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2118 | |
dc.description.abstract | Covalent attachment of the nitric oxide (NO) moiety to the HIV protease inhibitor Saquinavir (Saq) produced a new chemical entity, named Saquinavir-NO, (Saq-NO) with reduced toxicity and potent immunoregulatory influence on T lymphocytes. In this study, we have compared head-to-head the effects of Saq-NO and Saq on mouse and rat peritoneal macrophage cytokine secretion and NO production upon in vitro, ex vivo and in vivo conditions. The results demonstrate that Saq-NO, but not Saq, potently decreased interleukin (IL)-10, IL-6 and nitrite accumulation and increased the levels of IL-1 and tumour necrosis factor (TNF) in supernatants of mouse and rat macrophage cultures in vitro. Treatment of mice with Saq-NO, but not Saq, inhibited ex vivo secretion of IL-6 from macrophages. Consistent with these findings, Saq-NO also reduced blood levels of IL-6 in lipopolysaccharide-treated mice. The observed inhibitory influence of Saq-NO on IL-6 generation in macrophages may be involved in the observed antitumour and immunomodulatory effects of the drug. | en |
dc.description.sponsorship | Ministry of Education and Science of the Republic of Serbia {[}173013, 173035] | en |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Basic & Clinical Pharmacology & Toxicology | |
dc.title | Saquinavir-NO Inhibits IL-6 Production in Macrophages | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Миљковић, Ђорђе М.; Јевтић, Бојан; Ницолетти, Фердинандо; Маммана, Санта; Стошић-Грујичић, Станислава Д.; Мангано, Катиа; Момчиловић, Миљана Б.; | |
dc.citation.issue | 6 | |
dc.citation.volume | 115 | |
dc.identifier.doi | 10.1111/bcpt.12268 | |
dc.identifier.scopus | 2-s2.0-84925934097 | |
dc.identifier.wos | 000345341900004 | |
dc.citation.spage | 499 | |
dc.citation.epage | 506 | |
dc.type.version | publishedVersion | en |