Possible Influence of B Chromosomes on Genes Included in Immune Response and Parasite Burden in Apodemus flavicollis
2014
Аутори:
Adnađević, TanjaJovanović, Vladimir
Blagojević, Jelena
Budinski, Ivana
Cabrilo, Borislav
Bijelic-Cabrilo, Olivera
Vujošević, Mladen
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Genetic background underlying wild populations immune response to
different parasites is still not well understood. We studied immune
response to multiple infections and to competition between different
parasite species at different developmental stages in population of
yellow-necked mouse, Apodemus flavicollis. Quantitative real-time PCR
was used to investigate associations of MHC II-DRB, IL-10 and Tgf-beta
genes expressions with presence of intestinal parasites at different
developmental stages. Furthermore, we were interested whether the host
related characteristics (sex, age, body condition, presence of B
chromosomes or expression of other genes) or characteristics of present
parasites (number of adult parasites of each identified species, egg
count of each parasite genus, total number of nematode individuals)
affect differential expression of the studied genes. A significant
invert association between the expression of MHC II-DRB and Tgf-beta
gene was found, which together with absence of IL-10 association
confirmed modified Th2 as the main type of immune response to nematode
infections. Effect of recorded parasites and parasite life-cycle stage
on expression levels of MHC II-DRB gene was detected only through
interactions with host-related characteristics such as sex, age, and the
presence of B chromosomes. The presence of B chromosomes is associated
with lower expression level of Tgf-beta gene. Although the influence of
host genetic background on parasite infection has already been well
documented, this is the first study in mammals that gave presence of B
chromosomes on immune response full consideration.
Извор:
Plos One, 2014, 9, e112260Финансирање / пројекти:
- Генетичка и фенетичка разноврсност у природним популацијама у различитим срединама - допринос полиморфизма Б хромозома (RS-MESTD-Basic Research (BR or ON)-173003)
DOI: 10.1371/journal.pone.0112260
ISSN: 1932-6203
PubMed: 25372668