GR gene BclI polymorphysm changes the path, but not the level, of dexamethasone-induced cortisol suppression
2014
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Background: The hypothalamo-pituitary-adrenocortical (HPA) axis
self-regulation is achieved via cortisol binding to mineralocorticoid
(MR) and glucocorticoid receptors (GR). It is often disturbed in mental
disorders, particularly in those where traumatic stress has been
implicated, such as posttraumatic stress disorder and depression.
Although dexamethasone suppression test (DST) is often used as
diagnostic aid, the findings still vary. In search of the factors
influencing the DST outcome, we examined the glucocorticoicl receptor
(GR) gene Bell polymorphism.
Methods: A total of 229 male subjects were classified into three Bell
groups: two groups with homozygous carriers (of the G allele, N=108, and
of the C allele, N=26), and one with heterozygous carriers (N=95).
Multiple hierarchical linear regression analysis was clone, where the
dependent variable was the clexamethasone-inclucecl cortisol
suppression, and predictors included receptor variables. The
interactions of the count of `G's with the predictors were introduced to
single out the effects of the G allele.
Results: The means of all studied variables, including suppression, are
statistically the same in the three groups. However, the mechanism of
suppression involves MRs only in the G allele carriers. Limitations: The
subjects were selected by criteria suited for the aim of the large
project whose part is this study, hence the relatively small number of
CC carriers. Also, we did not assess MR functional properties that would
probably sharpen the results.
Conclusion: Our finding that MRs participate in cortisol suppression in
the G allele carriers suggests that research aimed at refining HPA
axis-based therapy might require its adjustment for such patients., (C)
2014 Elsevier By. All rights reserved.
Кључне речи:
Dexamethasone suppression test; Glucocorticoid receptor; Mineralocorticoid receptorИзвор:
Journal of Affective Disorders, 2014, 168, 1-4
DOI: 10.1016/j.jad.2014.06.046
ISSN: 1573-2517