dc.creator | Heleno, Sandrina A. | |
dc.creator | Ferreira, Isabel C. F. R. | |
dc.creator | Ćirić, Ana | |
dc.creator | Glamočlija, Jasmina | |
dc.creator | Martins, Anabela | |
dc.creator | Queiroz, Maria Joao R. P. | |
dc.creator | Soković, Marina | |
dc.date.accessioned | 2016-05-23T11:00:21Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 2042-650X | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2149 | |
dc.description.abstract | Despite the available data regarding antimicrobial activity of phenolic
acids, studies dealing with the effects of their metabolites or
derivatives are scarce. Therefore, the antimicrobial and demelanizing
activities of Coprinopsis atramentaria extract, its organic acids, and
methylated and glucuronated derivatives were evaluated. The antifungal
activity was stronger than the antibacterial effects. In general,
individual compounds (mostly organic acids) exhibited higher activity
than the extract and even higher than the standards used in the assays.
Methylated derivatives presented the highest demelanizing activity
toward Aspergillus niger, A. fumigatus and Penicillium verrucosum var.
cyclopium. The inclusion of methyl groups in the parental compound
(CoAM1, CoAM2 and CoAM3) strongly increased antibacterial and antifungal
activities of CoA, while the inclusion of acetyl groups (CoAGP)
increased the antifungal activity but the antibacterial properties were
maintained. For HA and CA, the inclusion of methyl groups (HAM1, HAM2,
HAM3 and CAM) increased the demelanizing activity, but decreased the
antimicrobial properties. The present work contributes to the knowledge
of the mechanisms involved in the antimicrobial properties of organic
acids namely, phenolic acids, usually present in mushrooms. Organic
acids, and methylated and glucuronated derivatives could be used as
antimicrobial agents. | en |
dc.language | English | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173032/RS// | |
dc.rights | restrictedAccess | |
dc.source | Food & Function | |
dc.title | Coprinopsis atramentaria extract, its organic acids, and synthesized
glucuronated and methylated derivatives as antibacterial and antifungal
agents | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Гламочлија, Јасмина; Соковић, Марина Д.; Qуеироз, Мариа Јоао Р. П.; Мартинс, Aнабела; Ћирић, Aна Д.; Ферреира, Исабел Ц. Ф. Р.; Хелено, Сандрина A.; | |
dc.rights.holder | © The Royal Society of Chemistry 2014 | |
dc.citation.issue | 10 | |
dc.citation.volume | 5 | |
dc.identifier.doi | 10.1039/c4fo00490f | |
dc.identifier.pmid | 25131614 | |
dc.identifier.scopus | 2-s2.0-84907808125 | |
dc.identifier.wos | 000343023300016 | |
dc.citation.spage | 2521 | |
dc.citation.epage | 2528 | |
dc.type.version | publishedVersion | en |