The impact of TP53 and RAS mutations on cerebellar glioblastomas
2014
Аутори:
Milinkovic, Vedrana P.Gazibara, Milica K. Skender
Gacic, Emilija M. Manojlovic
Gazibara, Tatjana M.
Tanić, Nikola
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Cerebellar glioblastoma (cGBM) is a rare, inadequately characterized
disease, without detailed information on its molecular basis. This is
the first report analyzing both TP53 and RAS alterations in cGBM. TP53
mutations were detected in more than half of the samples from our
cohort, mainly in hotspot codons. There were no activating mutations in
hotspot codons 12/13 and 61 of KRAS and HRAS genes in cGBM samples but
we detected alterations in other parts of exons2 and 3 of these genes,
including premature induction of STOP codon. This mutation was present
in 3 out of 5 patients. High incidence of RAS mutations, as well as
significantly longer survival of cGBM patients compared to those with
supratentorial GBM suggest that cGBM may have different mechanisms of
occurrence. Our results suggest that inactivation of TP53 and MS may
play an important role in the progression of cerebellar GBM. (C) 2014
Elsevier Inc. All rights reserved.