dc.creator | Lavrnja, Irena | |
dc.creator | Ajdžanović, Vladimir | |
dc.creator | Trifunović, Svetlana | |
dc.creator | Savić, Danijela | |
dc.creator | Milošević, Verica | |
dc.creator | Stojiljkovic, Mirjana | |
dc.creator | Peković, Sanja | |
dc.date.accessioned | 2016-05-23T11:00:23Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1097-4547 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2159 | |
dc.description.abstract | The pituitary appears to be vulnerable to brain trauma, and its
dysfunction is a common feature after traumatic brain injury. The role
of pituitary growth hormone (GH) in brain repair after injury has been
envisaged, but more studies must be performed to understand completely
the importance of GH in these processes. Because some of the
neuroprotective effects of GH are mediated directly through the GH
receptor (GHR), we examined GHR expression in the rat cerebral cortex
after sensorimotor cortex ablation. RT-PCR, immunohistochemistry, and
double immunofluorescence had been performed to analyze the correlation
between GHR expression in the injured cortex and activity of GH cells in
the pituitary. Our results showed that the volume of GH-immunopositive
cells was reduced at days 2 and 7 postsurgery (dps), and volume density
of GH cells was significantly decreased at 14 dps, all compared with
appropriate sham controls. At 30 dps all investigated parameters had
returned to control level. In the injured cortex, GHR expression was
transiently upregulated. Increased GHR immunoreactivity was observed in
reactive astrocytes at 7 and particularly at 14 dps. In neuronal cells,
an increase of GHR immunoreactivity was seen in neuronal cell bodies and
well-defined primary dendrites at 14 and especially at 30 dps. The
results presented here suggest that, during recovery from brain injury,
changes in activity of pituitary GH cells result in upregulation of GHR
that may have a role in neuronal arborization and glial proliferation in
the injured cortex. (C) 2014 Wiley Periodicals, Inc. | en |
dc.description.sponsorship | Ministry of Education, Science, and Technological Development of the
Republic of Serbia {[}III 41014, ON 173009] | |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Journal of Neuroscience Research | |
dc.subject | growth hormone | |
dc.subject | glia scar | |
dc.subject | pituitary gland | |
dc.subject | traumatic brain injury | |
dc.subject | growth hormone receptor | |
dc.title | Cortical Ablation Induces Time-Dependent Changes in Rat Pituitary
Somatotrophs and Upregulates Growth Hormone Receptor Expression in the
Injured Cortex | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Aјджановић, Владимир; Лаврња, Ирена Ц.; Трифуновиц, Светлана; Милосевиц, Верица; Савиц, Данијела; Стојиљковиц, Мирјана; Пековић, Сања; | |
dc.citation.issue | 10 | |
dc.citation.volume | 92 | |
dc.identifier.doi | 10.1002/jnr.23408 | |
dc.identifier.scopus | 2-s2.0-84905862534 | |
dc.identifier.wos | 000340504500011 | |
dc.citation.spage | 1338 | |
dc.citation.epage | 1349 | |
dc.type.version | publishedVersion | en |