Hepatoprotective effects of secoiridoid-rich extracts from Gentiana cruciata L. against carbon tetrachloride induced liver damage in rats
2014
Аутори:
Mihailović, VladimirKatanić, Jelena
Mišić, Danijela
Stanković, Vesna
Mihailović, Mirjana
Uskoković, Aleksandra
Arambašić Jovanović, Jelena
Solujić, Slavica
Mladenović, Milan
Stanković, Nevena
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2014 by The Royal Society of Chemistry
Метаподаци
Приказ свих података о документуАпстракт:
The objective of this work was to investigate the effects of the
methanol extracts of Gentiana cruciata L. aerial parts (GCA) and roots
(GCR) against carbon tetrachloride-induced liver injury in rats.
Pretreatment with GCA and GCR, containing sweroside, swertiamarin and
gentiopicrin in high concentrations, dose-dependently and significantly
decreased the levels of serum transaminases, alkaline phosphatase and
total bilirubin, whereas an increase in the level of total protein was
found compared with the CCl4-treated group. Moreover, oral
administration of extracts significantly enhanced antioxidant enzyme
activities (superoxide dismutase and catalase), increased the content of
glutathione and decreased the content of TBARS. Microscopic evaluations
of the liver revealed CCl4-induced lesions and related toxic
manifestations that were minimal in the liver of rats pretreated with
extracts at the dose of 400 mg per kg b.w. The results suggest that the
use of G. cruciata extracts has a merit as a potent candidate in
protecting the liver against chemical induced toxicity.
Извор:
Food and Function, 2014, 5, 8, 1795-1803
DOI: 10.1039/c4fo00088a
ISSN: 2042-650X
PubMed: 24912992