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Carbon Monoxide-Releasing Molecule-A1 Inhibits Th1/Th17 and Stimulates Th2 Differentiation In vitro
dc.creator | Nikolić, Ivana | |
dc.creator | Vujičić, Milica | |
dc.creator | Stojanović, Ivana D. | |
dc.creator | Stošić-Grujičić, Stanislava | |
dc.creator | Saksida, Tamara | |
dc.date.accessioned | 2016-05-23T11:00:29Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1365-3083 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2183 | |
dc.description.abstract | Carbon monoxide (CO) is endogenously produced by haeme oxygenase-1 and has profound effects on intracellular signalling processes, generating anti-inflammatory, antiproliferative and antiapoptotic effects. A boron-containing compound CORM-A1 is capable of releasing CO in such a way to mimic physiological functions of haeme oxygenase-1. Considering the importance of Th1/Th17 versus Th2 balance in the final outcome of immune and inflammatory responses in this study we focused on immune-modulatory effects of CORM-A1 on murine lymph node-derived T cells in vitro and its influence on T-cell proliferation, activation and differentiation. Anti-CD3/CD28 antibody-triggered lymph node cells proliferation remained unaffected after 24-hour CORM-A1 treatment, as well as the expression of the early activation marker CD25. However, CORM-A1 successfully reduced the secretion of the two representative pro-inflammatory cytokines, IFN-gamma and IL-17, while the secretion of anti-inflammatory cytokine IL-4 remained unchanged. Furthermore, CORM-A1 efficiently reduced the percentage of CD4(+)IFN-gamma(+) and CD4(+)IL-17(+) cells, whereas CD4(+)IL-4(+) cell population increased after treatment. Also, CORM-A1 significantly reduced expression of transcription factor ROR gamma T, necessary for Th17 development, but the expression of Th1-related and Th2-related transcription factors (T-bet and GATA-3, respectively) remained unchanged. In conclusion, our findings indicate that CO has anti-inflammatory role through the regulation of balance between pro-inflammatory Th1/Th17 and anti-inflammatory Th2 cells. Observed immunomodulatory effects of CORM-A1 could be useful for developing novel therapeutic approaches in managing Th1/Th17-mediated immune disorders. | en |
dc.description.sponsorship | EFSD New Horizons Collaborative Research Initiative; Ministry of Education, Science and Technological Development, Republic of Serbia {[}173013] | en |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Scandinavian Journal of Immunology | |
dc.title | Carbon Monoxide-Releasing Molecule-A1 Inhibits Th1/Th17 and Stimulates Th2 Differentiation In vitro | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Саксида, Тамара; Вујичић, Милица; Стошић-Грујичић, Станислава Д.; Николић, Ивана; Стојановиц, И.; | |
dc.citation.issue | 2 | |
dc.citation.volume | 80 | |
dc.identifier.doi | 10.1111/sji.12189 | |
dc.identifier.scopus | 2-s2.0-84903906605 | |
dc.identifier.wos | 000339431700003 | |
dc.citation.spage | 95 | |
dc.citation.epage | 100 | |
dc.type.version | publishedVersion | en |
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