Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq.
2014
Аутори:
Zivkovic, JelenaBarreira, Joao C. M.
Stojković, Dejan
Cebovic, Tatjana
Santos-Buelga, Celestino
Maksimovic, Zoran
Ferreira, Isabel C. F. R.
Тип документа:
Чланак у часопису (Рецензирана верзија)
Метаподаци
Приказ свих података о документуАпстракт:
The phenolic profile and antibacterial, antimutagenic and antitumour
activities of the methanolic extracts of Veronica urticifolia Jacq. were
evaluated. HPLC-DAD/ESI-MS analysis revealed the presence of phenolic
acids, flavonoids and phenylethanoids, with acteoside as the main
component (14.9 mg/g of extract). Antibacterial effect was determined
using the microbroth dilution assay and Staphylococcus aureus was the
most sensitive strain (MIC and MBC = 7.5 mg/mL). Antimutagenic activity
was evaluated by Ames mutagenicity assay. At 1 mg/plate, the tested
extract afforded high protection against the mutagenicity of
nitroquinoline-N-oxide (4NQO) to Salmonella typhimurium strain TA100
(inhibition rate 48.3\%). Antitumour activity was screened in Ehrlich
ascites carcinoma (EAC) model. Pretreatment with 2 mg/kg body weight
showed statistically significant decrease in tumour cell viability,
while ascites volume and tumour cell count became slightly decreased,
but not to a statistically significant extent. The results indicate that
V. urticifolia deserves further research into its potential
chemoprevention effects. (C) 2014 Elsevier Ltd. All rights reserved.
Напомена:
This is the accepted manuscript version of the following article: Živković J, Barreira JCM, Stojković D, Ćebović T, Santos-Buelga C, Maksimović Z, Ferreira ICFR. Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq. J Funct Foods. 2014;9(1):192-201.https://doi.org/10.1016/j.jff.2014.04.024
Кључне речи:
Veronica urticifolia; Phenolic profile; Antibacterial; Antimutagenicity; Ehrlich carcinomaИзвор:
Journal of Functional Foods, 2014, 9, 192-201Финансирање / пројекти:
- Биотехнологија ин витро - гајене, лековите и угрожене биљне врсте (RS-MESTD-Basic Research (BR or ON)-173015)
- PEst-OE/AGR/UI0690/2011
- SFRH/BPD/72802/2010
- Spanish Government through the Consolider-Ingenio 2010 Programme (FUN-C-FOOD, CSD2007-00063) and project ref. BFU2012-35228
DOI: 10.1016/j.jff.2014.04.024
ISSN: 1756-4646