Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in Cancer Treatment
2014
Аутори:
Bulatović, Mirna Z.Maksimović-Ivanić, Danijela
Bensing, Christian
Gomez-Ruiz, Santiago
Steinborn, Dirk
Schmidt, Harry
Mojić, Marija
Korac, Aleksandra
Golic, Igor
Perez-Quintanilla, Damian
Momčilović, Miljana
Mijatović, Sanja
Kaluđerović, Goran N.
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
The strong therapeutic potential of an organotin(IV) compound loaded in
nanostructured silica (SBA-15pSn) is demonstrated: B16 melanoma tumor
growth in syngeneic C57BL/6 mice is almost completely abolished. In
contrast to apoptosis as the basic mechanism of the anticancer action of
numerous chemotherapeutics, the important advantage of this SBA-15pSn
mesoporous material is the induction of cell differentiation, an effect
unknown for metal-based drugs and nanomaterials alone. This
non-aggressive mode of drug action is highly efficient against cancer
cells but is in the concentration range used nontoxic for normal tissue.
JNK (Jun-amino-terminal kinase)-independent apoptosis accompanied by the
development of the melanocyte-like nonproliferative phenotype of
survived cells indicates the extraordinary potential of SBA-15pSn to
suppress tumor growth without undesirable compensatory proliferation of
malignant cells in response to neighboring cell death.
Кључне речи:
cell differentiation; cisplatin; drug delivery; melanoma; nanostructuresИзвор:
Angewandte Chemie-International Edition, 2014, 53, 23, 5982-5987
DOI: 10.1002/anie.201400763
ISSN: 1521-3773